Metagenomic insights into the effects of nanobubble water on the composition of gut microbiota in mice

Bo Hu, Hanlin Han, Kazuya Shimizu, Liang Zhang, Zhenya Zhang, Zhongfang Lei, Zitao Guo

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DOI: 10.1039/d0fo01592j DOI is the universal ID for this study.

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The particular physicochemical and biological properties of nanobubbles (NBs) have prompted many researchers to conduct an in-depth study on their potential application in various fields. This study aims to investigate the effects of nanobubble water (NBW) on the community structure of the gut microbiota in mice. In this study, supplementation with nitrogen NBW (SD-N2 group), hydrogen NBW (SD-H2 group) and deionized water (SD-C group) to a standard diet of mice was performed for five weeks. The composition of fecal microbiota was analyzed by using 16S rRNA gene sequencing. Compared with the SD-C group, the species diversity of the fecal microbiota in mice in NBW groups was significantly increased. At the genus level, supplementation with nitrogen NBW to mice significantly increased the relative abundance of two beneficial genera Clostridium and Coprococcus (mean growth 6.3 times and 9.7 times, respectively), while supplementation with hydrogen NBW significantly decreased the relative abundance of two pathogenic genera Mucispirillum and Helicobacter (mean reduction rate 86% and 60%, respectively). These results demonstrate that supplementation with NBW might optimize the composition of gut microbiota in mice.

Publish Year 2020
Country China
Rank Positive
Journal Food & Function
Primary Topic Intestine
Secondary TopicBacterial Infection
Model Mouse
Tertiary TopicGut Microbiome
Vehicle Water (Dissolved)
pH Neutral
Application Ingestion