Investigation of protective effect of hydrogen-rich water against cisplatin-induced nephrotoxicity in rats using blood oxygenation level-dependent magnetic resonance imaging
Akihiro Kitamura, Kenya Murase, Sakie Okada, Taro Matsushita, Yoshinori Kusakabe
Abstract:
The aim of this study was to assess the mechanism of the protective effect of hydrogen-rich water (HW) against cisplatin (CP)-induced nephrotoxicity in rats using blood oxygenation level-dependent (BOLD) magnetic resonance imaging (MRI). Apparent transverse relaxation time-weighted images (T2 WI) were acquired in 28 rats. The control group (n = 7) had free access to standard water (SW) and no CP injection. The CP group (n = 7) had free access to SW and was given a CP injection on day 0. The CP+HW group (n = 7) had free access to HW and had a CP injection. The HW group (n = 7) had free access to HW and no CP injection. The apparent transverse relaxation rate (R2) was estimated from T2 WI. In the CP+HW group, the R2 value in the medulla normalized by the value of the day 0 was significantly greater than that in the CP group on days 4 and 7. The creatinine and blood urea nitrogen levels in the CP group were significantly higher than those in the control, CP+HW, and HW groups. BOLD MRI may be useful for demonstrating the change in R2 in CP-induced nephrotoxicity in rats. The changes in the CP+HW group were suspected to be due to a reduction of cytotoxic oxygen radicals.
| Publish Year |
2011 |
| Country |
Japan |
| Rank |
Positive |
| Journal |
Japanese Journal of Radiology |
| Primary Topic |
Kidney |
| Secondary Topic | Cancer |
| Model |
Rat |
| Tertiary Topic | Chemotherapy Toxicity (Cisplatin) |
| Vehicle |
Water (Dissolved) |
| pH |
Neutral |
| Application |
Ingestion |
| Comparison |
|
| Complement |
|
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