In vivo X-ray triggered catalysis of H2 generation for cancer synergistic gas-radiotherapy
Huanghao Yang, Jiamin Ye, Jibin Song, Lichao Su, Meng Yuan, Tao Chen, Yifan Jiang, Ying Wu
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DOI:
10.1002/anie.202100002
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Abstract:
To date, hydrogen (H2) therapy has received widespread attention. However, X-ray triggered sustainable H2-producing materials with controlled release for cancer treatment have not been reported. Herein, an X-ray triggered sustainable in situ H2 producing platform, Au NR-TiO2@ZnS:Cu,Co-A(Au-TiO2@ZnS), composed of Au-amorphous TiO2 nano-dumbbell-shaped heterostructure coated with long afterglow particles, was developed for cancer synergistic H2-radiotherapy. The mechanism of H2 production was verified by theoretical calculations and in vitro experiments. Changes in the apoptosis pathway caused by the synergistic effect of H2 and radiotherapy were reported. Guided by its excellent photoacoustic imaging capabilities, mice with orthotopic liver cancer achieved excellent therapeutic effects and low inflammatory side effects, suggesting that Au-TiO2@ZnS has promising application potential for cancer treatment and prognosis.
| Publish Year |
2021 |
| Country |
China |
| Rank |
Positive |
| Journal |
Angewandte Chemie |
| Primary Topic |
Liver |
| Secondary Topic | Cancer |
| Model |
Mouse |
| Tertiary Topic | Novel Therapy |
| Vehicle |
Gas (Sustained Release) |
| pH |
N/A |
| Application |
Implantation |
| Comparison |
|
| Complement |
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