Hydrogen-rich saline ameliorates the retina against light-induced damage in rats
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DOI:
10.1186/2045-9912-3-19
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Abstract:
Oxidative reactions are thought to be a major cause of light-induced retinal degeneration. This study was designed to investigate the effects of hydrogen-rich saline (HRS) on the prevention and treatment of light-induced retinal injury in rats. Male Sprague--Dawley rats were divided randomly into three groups: light damage, HRS prevention (5 ml/kg, 30 min before intensive light exposure), and HRS treatment (5 ml/kg per day for 5 days, after intensive light exposure), respectively. The right eye of each rat was exposed to 5000 lux constant white light-emitting diode (LED) light for 3 h, and the left eye was covered to serve as the blank control. Electroretinograms were recorded 5 days later, and the thickness of the outer nuclear layer (ONL) was measured after hematoxylin and eosin (H&E) staining. The results showed that the electroretinogram b-wave amplitudes and the mean ONL thicknesses of rats were significantly greater in the HRS prevention (P < 0.001) and treatment (P < 0.001) groups than in the light damage. These results indicated that peritoneal injection of HRS provides protection and treatment against light-induced retinal degeneration in rats.| Publish Year | 2013 |
|---|---|
| Country | China |
| Rank | Positive |
| Journal | Medical Gas Research |
| Primary Topic | Eye |
| Secondary Topic | Radioprotection |
| Model | Rat |
| Tertiary Topic | Light Damage |
| Vehicle | Saline (Dissolved) |
| pH | Neutral |
| Application | Injection |
| Comparison | |
| Complement |