Hydrogen mediates suppression of colon inflammation induced by dextran sodium sulfate
Kazuhisa Ouhara, Kimihiro Sato, Marcelo J. B. Silva, Mikihito Kajiya, Toshihisa Kawai
Abstract:
By its antioxidant effect, molecular hydrogen gas (H2) was reported to protect organs from tissue damage induced by ischemia reperfusion. To evaluate its anti-inflammatory effects, we established a mouse model of human inflammatory bowel disease (IBD) by supplying mice with water containing (1) dextran sodium sulfate (DSS) (5%), (2) DSS (5%) and H2, or (3) H2 only ad libitum up to 7 days. At day-7, DSS-induced pathogenic outcomes including, loss of body weight, increase of colitis score, pathogenic shortening of colon length, elevated level of IL-12, TNF-alpha and IL-1beta in colon lesion, were significantly suppressed by the addition of H2 to DSS solution. Histological analysis also revealed that the DSS-mediated colonic tissue destruction accompanied by macrophage infiltration was remarkably suppressed by H2. Therefore, the present study indicated that H2 can prevent the development of DSS-induced colitis in mice.
| Publish Year |
2009 |
| Country |
United States |
| Rank |
Positive |
| Journal |
Biochemical and Biophysical Research Communications |
| Primary Topic |
Intestine |
| Secondary Topic | Inflammatory Bowel Disease |
| Model |
Mouse |
| Tertiary Topic | Oxidative Stress |
| Vehicle |
Water (Dissolved) |
| pH |
Neutral |
| Application |
Ingestion |
| Comparison |
|
| Complement |
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