Hepatoprotective effect of electrolyzed reduced water against carbon tetrachloride-induced liver damage in mice

Cheng-Chieh Yen, Chia-Fang Tsai, Fung-Jou Lu, Wen-Huei Chang, Wen-Kang Chen, Yu-Wen Hsu, Yung-Chyuan Ho

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DOI: 10.1016/j.fct.2009.05.021 DOI is the universal ID for this study.

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The study investigated the protective effect of electrolyzed reduced water (ERW) against carbon tetrachloride (CCl(4))-induced liver damage. Male ICR mice were randomly divided into control, CCl(4), CCl(4)+silymarin, and CCl(4)+ERW groups. CCl(4)-induced liver lesions include leukocytes infiltration, hepatocyte necrosis, ballooning degeneration, mitosis, calcification, fibrosis and an increase of serum alanine aminotransferase (ALT), and aminotransferase (AST) activity. In addition, CCl(4) also significantly decreased the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px). By contrast, ERW or silymarin supplement significantly ameliorated the CCl(4)-induced liver lesions, lowered the serum levels of hepatic enzyme markers (ALT and AST) and increased the activities of SOD, catalase, and GSH-Px in liver. Therefore, the results of this study show that ERW can be proposed to protect the liver against CCl(4)-induced oxidative damage in mice, and the hepatoprotective effect might be correlated with its antioxidant and free radical scavenging effect.

Publish Year 2009
Country Taiwan
Rank Positive
Journal Food and Chemical Toxicology
Primary Topic Liver
Secondary TopicLiver Disease
Model Mouse
Tertiary TopicFibrosis
Vehicle Water (Electrolysis)
pH Alkaline
Application Ingestion