Effects of hydrogen-rich water on aging periodontal tissues in rats

Daisuke Ekuni, Kenta Kasuyama, Manabu Morita, Mayu Yamane, Takaaki Tomofuji, Tatsuji Azuma, Toshiki Yoneda, Yasymasa Endo, Yuya Kawabata

Read more:

DOI: 10.1038/srep05534 DOI is the universal ID for this study.

This link will take you to the full study.


Oxidative damage is involved in age-related inflammatory reactions. The anti-oxidative effects of hydrogen-rich water suppress oxidative damage, which may aid in inhibiting age-related inflammatory reactions. We investigated the effects of drinking hydrogen-rich water on aging periodontal tissues in healthy rats. Four-month-old male Fischer 344 rats (n = 12) were divided into two groups: the experimental group (hydrogen-rich water treatment) and the control group (distilled water treatment). The rats consumed hydrogen-rich water or distilled water until 16 months of age. The experimental group exhibited lower periodontal oxidative damage at 16 months of age than the control group. Although protein expression of interleukin-1β did not differ, gene expression of Nod-like receptor protein 3 inflammasomes was activated in periodontal tissues from the experimental group as compared with the control group. Drinking hydrogen-rich water is proposed to have anti-aging effects on periodontal oxidative damage, but not on inflammatory reactions in healthy rats.

Publish Year 2014
Country Japan
Rank Positive
Journal Nature Scientific Reports
Primary Topic Mouth
Secondary TopicPeriodontitis
Model Rat
Tertiary TopicInflammation
Vehicle Water (Dissolved)
pH Neutral
Application Ingestion