Effectiveness Of Molecular Hydrogen In The Management Of Musculotendinous Injuries

Jay R. Hoffman, Marko D. Stojanovic, Sergej M. Ostojic

Read more:

DOI: 10.1249/01.mss.0000493783.80014.95 DOI is the universal ID for this study.

This link will take you to the full study.


Muscle and tendon strains (MTS) are often accompanied by subsequent tissue hypoxia and overproduction of reactive oxygen species; this may aggravate the initial cellular damage caused by the actual mechanism of injury. Molecular hydrogen (H2) seems to be beneficial for treating ischemia-reperfusion injury, oxidative stress, and inflammation in human diseases; however, the effects of H2 as an element of acute management of musculotendinous injuries are unclear. PURPOSE: To examine the effects of one-week oral and topical H2 administration on markers of inflammation, functional recovery and pain intensity in competitive male athletes after acute MTS. METHODS: During the 2013 competitive season (from March to May) participants (12 professional athletes) were recruited and examined by a certified sports medicine specialist in the first 24 hours after a MTS was sustained. The subjects were allocated in a double-blind design to two randomly assigned trials: control group (CON) received a traditional treatment protocol after the soft-tissue injury (first 48 h: rest, ice packs for 20 min every 2 h, compression with elastic bandage, elevation of the injured area above the level of the heart at all possible times; next 5 days: passive stretching 3 times per day for 90 sec, isometric strength exercise with 3 sets with 15 reps, 30 min of pain-free weight-bearing exercise); experimental group (HYD) followed the above procedures with additional administration of oral H2 tablets (2 g/day) and topical hydrogen-rich packs (6 times per day for 20 min). Participants were evaluated at the time of the injury report and 7 days after baseline testing. RESULTS: HYD intervention augmented the decrease in plasma viscosity as compared to the CON (20.7 ± 2.4 vs. 15.4 ± 1.9%; p = 0.002). Limb swelling was reduced in both groups at post-intervention, with the decline in limb circumference significantly higher in the HYD (8.0 ± 1.6 vs. 6.2 ± 0.7%; p = 0.04). CONCLUSION: The addition of oral and topical molecular hydrogen to traditional first-line treatment is effective in the management of musculotendinous injuries in athletes.

Publish Year 2014
Country Serbia
Rank Positive
Journal Medicine and Science in Sports and Exercise
Primary Topic Tendon
Secondary TopicExcercise
Model Human
Tertiary TopicSprain
Vehicle Gas (Sustained Release)
pH Neutral
Application Mixed