Changes of nasal nitric oxide in the treatment of allergic rhinitis with hydrogen-rich saline lavage of nasal cavity

Kai Fan, Ling Jin, Qin Ge, Shaoqing Yu, Xi Zhang, Yang Wang, Yihua Zhao

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DOI: 10.13201/j.issn.2096-7993.2020.03.014 DOI is the universal ID for this study.

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Objective:To observe the effect of hydrogen-rich saline on the concentration of nitric oxide in the nose, and to explore the mechanism of its treatment of allergic rhinitis. Method:Twenty patients with moderate to severe persistent allergic rhinitis were enrolled in a randomized, double-blind, self-controlled study. The nasal cavity was lavaged with hydrogen-rich normal saline and normal saline, and the nasal nitric oxide(nNO) value was tested weekly. Result:The test value of nNO was correlated with the diagnosis and curative effect of allergic rhinitis. The difference of nNO test values before and after treatment of the two lavage fluids was statistically significant(P<0.01).

Conclusion:Hydrogen-rich saline lavage can cause nNO change in nasal cavity which may be used in the treatment of allergic rhinitis.

Publish Year 2020
Country China
Rank Positive
Journal Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
Primary Topic Nose
Secondary TopicRhinitis
Model Human
Tertiary TopicInflammation
Vehicle Saline (Dissolved)
pH Neutral
Application Irrigation