Case Report: Buccal administration of hydrogen-producing blend after a mild traumatic brain injury in a professional athlete

Dejan Javorac, Sergej M. Ostojic, Valdemar Stajer

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DOI: 10.12688/f1000research.19739.1 DOI is the universal ID for this study.

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Background: Sport-related mild traumatic brain injury (TBI) is a serious trauma that could impair brain function of an injured athlete. Treatment solutions for mild TBI typically concentrate on complete rest, while non-traditional therapeutic options remain largely ineffective. Molecular hydrogen (H 2 ) is an innovative neuroprotective agent that can easily reach the brain, yet no data are available concerning its value as a first-aid intervention after a mild TBI. Case report: This case report demonstrates the efficacy and safety of a hydrogen-producing dissolving tablet administered buccally during the first 24 hours post-injury in a professional soccer player who suffered a mild TBI. The patient received a formulated dosage of hydrogen every 2 hours, with the first intervention given immediately after an initial examination (~ 15 min after the injury). The overall score for Sport Concussion Assessment Tool 2 (SCAT2), a standardized method of evaluating injured athletes for concussion, increased from 68 points (severe disruption) at baseline to 84 points (mild disruption) at 24-h follow-up. The patient reported no side effects of hydrogen intervention. Conclusions: This case has demonstrated that intensive consecutive therapy with oral transmucosal hydrogen formulation is a beneficial strategy with regard to the reduction of presence and severity of symptoms of sport-related mild TBI.

Publish Year 2019
Country Serbia
Rank Positive
Journal F1000 Research
Primary Topic Brain
Secondary TopicTraumatic Brain Injury
Model Human
Tertiary TopicNovel Therapy
Vehicle Gas (Sustained Release)
pH N/A
Application Ingestion