Anti-inflammatory effect of hydrogen-rich saline in a rat model of regional myocardial ischemia and reperfusion
Read more:
DOI:
10.1016/j.ijcard.2010.08.058
DOI is the universal ID for this study.
This link will take you to the full study.
Abstract:
To study the possible anti-inflammatory effect of hydrogen-rich saline (H(2) saline) on rat hearts with regional myocardial ischemia and reperfusion (I/R). Sixty-six rats were equally randomized to three groups: sham-operated group, I/R group (control group) and I/R plus H(2) saline treatment group. Myocardial I/R was established by occlusion of the left anterior descending (LAD) coronary artery for 30 min and reperfusion for 24 h. H(2) saline treatment attenuated I/R-induced cardiac cell apoptosis, presenting as significant improvement of heart function parameters 24h after reperfusion, including left ventricular systolic pressure (LVSP), left ventricular diastolic pressure (LVEDP), +(dP/dt)max and -(dP/dt)max. It also decreased neutrophil infiltration, 3-nitrotyrosine level, expression of intercellular adhesion molecule 1(ICAM-1) and myeloperoxidase (MPO) activity in the area at risk zones (AAR) of rat hearts subjected to regional myocardial I/R, and attenuated the increase of I/R induced proinflammatory cytokine tumor necrosis factor-α (TNF-a) and interleukin-1β (IL-1b) levels in the AAR. H(2) saline has an anti-inflammatory effect on rat hearts with regional myocardial I/R.| Publish Year | 2011 |
|---|---|
| Country | China |
| Rank | Positive |
| Journal | International Journal of Cardiology |
| Primary Topic | Heart |
| Secondary Topic | Heart Attack |
| Model | Rat |
| Tertiary Topic | Ischemia-Reperfusion Injury |
| Vehicle | Saline (Dissolved) |
| pH | Neutral |
| Application | Injection |
| Comparison | |
| Complement |