Search

Studies Found: 230

BRAIN - PARKINSON'S DISEASE

Oral ‘hydrogen water’ induces neuroprotective ghrelin secretion in mice

Year Published: 2013

The therapeutic potential of molecular hydrogen (H₂) is emerging in a number of human diseases and in their animal models, including in particular Parkinson's disease (PD). H₂ supplementation of drinking water has been shown to exert disease-modifying effects in PD patients and neuroprotective effects in experimental PD model mice. However, H₂ supplementation does not result in detectable ...
BRAIN - CARDIAC ARREST

The neuroprotective effects of intraperitoneal injection of hydrogen in rabbits with cardiac arrest

Year Published: 2013

Objective: The purpose of this study was to investigate the neuroprotective effects of intraperitoneal injection of hydrogen (H2) in rabbits with cardiac arrest (CA). Methods: A rabbit model of CA was established by the delivery of alternating current between the esophagus and chest wall to induce ventricular fibrillation. Before CA, the animals were randomly divided into four groups: a sham group ...
BRAIN - NEUROPATHIC PAIN

Hydrogen-rich saline attenuated neuropathic pain by reducing oxidative stress

Year Published: 2013

Background: Reactive oxygen species (ROS) are often associated with persistent pains such as neuropathic and inflammatory pain. Hydrogen gas can reduce ROS and alleviate cerebral, myocardial, and hepatic ischemia/reperfusion injuries. In the present study, we aim to investigate whether hydrogen-rich saline can reduce neuropathic pain in a rat model of chronic constriction injury (CCI). Methods: ...
BRAIN - NEUROPROTECTION

Hydrogen-rich saline prevents remifentanil-induced hyperalgesia and inhibits MnSOD nitration via ...

Year Published: 2014

Remifentanil administration may subsequently cause paradoxical hyperalgesia in animals and humans, but mechanisms remain unclear. MnSOD nitration and inactivation caused by generation of reactive oxygen species and activation of NMDA receptors are involved in the induction and maintenance of central neuropathic pain. Hydrogen which selectively removes superoxide has gained much attention in recent ...
BRAIN - NEUROPROTECTION

Hydrogen-rich saline controls remifentanil-induced hypernociception and NMDA receptor NR1 subunit ...

Year Published: 2014

Background: Although NMDAR trafficking mediated by GSK-3β involvement in transmission of pronociceptive messages in the spinal cord has been confirmed by our previous studies, whether NMDAR trafficking is implicated in peripheral sensitization remains equivocal. It is demonstrated that inflammation is associated with spinal NMDAR-containing nociceptive neurons activation and the maintenance of ...
BRAIN - BRAIN INJURY

Physiological effects of combination therapy of intracisternal infusion of magnesium sulfate ...

Year Published: 2014

Combination therapy of intracisternal (ic) infusion of magnesium sulfate solution and intravenous (iv) injection of hydrogen-enriched fluid can provide protection against delayed ischemic neurological deficits after subarachnoid hemorrhage (SAH). However, the effects of this therapy on physiological parameters in vivo remain unclear. In this study, the effects of combination therapy were ...
BRAIN - ENVIRONMENTAL POLLUTION

Oral intake of hydrogen-rich water ameliorated chlorpyrifos-induced neurotoxicity in rats

Year Published: 2014

Chronic exposure to low-levels of organophosphate (OP) compounds, such as chlorpyrifos (CPF), induces oxidative stress and could be related to neurological disorders. Hydrogen has been identified as a novel antioxidant which could selectively scavenge hydroxyl radicals. We explore whether intake of hydrogen-rich water (HRW) can protect Wistar rats from CPF-induced neurotoxicity. Rats were gavaged ...
BRAIN - TRAUMATIC BRAIN INJURY

Attenuation of diffuse axonal injury by intraperitoneal injection of hydrogen via reducing oxidative ...

Year Published: 2014

To investigate the role of oxidative stress in diffuse axonal injury (DAI) and the therapeutic action of hydrogen in DAI models. Methods Totally 118 adult male SD rats were divided into 3 groups with 39 in each: sham, DAI, and DAI + hydrogen treatment. Rat diffuse axonal injury was induced by an experimental facility, which was developed to make the rat head spin 90 degrees at the moment to cause ...
BRAIN - SEPSIS

Protective effects of inhaled hydrogen gas on cognitive function in mice with sepsis-associated ...

Year Published: 2014

To evaluate protective effects of inhaled hydrogen gas (H2) on cognitive function in a murine model of sepsis-associated encephalopathy (SAE). A total of 84 male ICR mice, weighing 20-25 g, aged 6-8 weeks, were randomly divided into 4 groups of sham, sham+H2, sepsis and sepsis+H2. Sepsis was established by cecal ligation and puncture (CLP). Mice in sham+H2 and sepsis+H2 groups received 2% H2 ...
BRAIN - SEPSIS

Inhalation of hydrogen gas attenuates brain injury in mice with cecal ligation and puncture via ...

Year Published: 2014

During the development of sepsis, the complication in central nervous system (CNS), appearing early and frequently relative to other systems, can obviously increase the mortality of sepsis. Moreover, sepsis survivors also accompany long-term cognitive dysfunction, while the ultimate causes and effective therapeutic strategies of brain injury in sepsis are still not fully clear. We designed this ...
BRAIN - NEUROPATHIC PAIN

Molecular hydrogen attenuates neuropathic pain in mice

Year Published: 2014

Neuropathic pain remains intractable and the development of new therapeutic strategies are urgently required. Accumulating evidence indicates that overproduction of oxidative stress is a key event in the pathogenesis of neuropathic pain. However, repeated intra-peritoneal or intrathecal injections of antioxidants are unsuitable for continuous use in therapy. Here we show a novel therapeutic method ...
BRAIN - AGING

Electrochemically reduced water protects neural cells from oxidative damage

Year Published: 2014

Aging-related neurodegenerative disorders are closely associated with mitochondrial dysfunction and oxidative stresses and their incidence tends to increase with aging. Brain is the most vulnerable to reactive species generated by a higher rate of oxygen consumption and glucose utilization compared to other organs. Electrochemically reduced water (ERW) was demonstrated to scavenge reactive oxygen ...
BRAIN - CARDIOPULMONARY RESUSCITATION (CPR)

Hydrogen-rich saline improves survival and neurological outcome after cardiac arrest and ...

Year Published: 2014

Background: Sudden cardiac arrest is a leading cause of death worldwide. Three-fourths of cardiac arrest patients die before hospital discharge or experience significant neurological damage. Hydrogen-rich saline, a portable, easily administered, and safe means of delivering hydrogen gas, can exert organ-protective effects through regulating oxidative stress, inflammation, and apoptosis. We ...
BRAIN - CARDIOPULMONARY RESUSCITATION (CPR)

Hydrogen Inhalation During Normoxic Resuscitation Improves Neurological Outcome in a Rat Model of ...

Year Published: 2014

Background: We have previously shown that hydrogen (H2) inhalation, begun at the start of hyperoxic cardiopulmonary resuscitation, significantly improves brain and cardiac function in a rat model of cardiac arrest. Here, we examine the effectiveness of this therapeutic approach when H2 inhalation is begun on the return of spontaneous circulation (ROSC) under normoxic conditions, either alone or in ...
BRAIN - BRAIN INJURY

Neuroprotective Effect of Hydrogen-Rich Saline against Neurologic Damage and Apoptosis in Early ...

Year Published: 2014

Backgrounds: Early brain injury (EBI) plays a key role in the pathogenesis of subarachnoid hemorrhage (SAH). Neuronal apoptosis is involved in the pathological process of EBI. Hydrogen can inhibit neuronal apoptosis and attenuate EBI following SAH. However, the molecular mechanism underlying hydrogen-mediated anti-apoptotic effects in SAH has not been elucidated. In the present study, we aimed to ...
BRAIN - NEUROPATHIC PAIN

Intrathecal Infusion of Hydrogen-Rich Normal Saline Attenuates Neuropathic Pain via Inhibition of ...

Year Published: 2014

Background Reactive oxygen and nitrogen species are key molecules that mediate neuropathic pain. Although hydrogen is an established antioxidant, its effect on chronic pain has not been characterized. This study was to investigate the efficacy and mechanisms of hydrogen-rich normal saline induced analgesia. Methodology/Principal findings In a rat model of neuropathic pain induced by L5 spinal ...
BRAIN - BRAIN INJURY

Hydrogen-rich saline attenuates neuronal ischemia – Reperfusion injury by protecting ...

Year Published: 2014

Background: Hydrogen, a popular antioxidant gas, can selectively reduce cytotoxic oxygen radicals and has been found to protect against ischemia–reperfusion (I/R) injury of multiple organs. Acute neuronal death during I/R has been attributed to loss of mitochondrial permeability transition coupled with mitochondrial dysfunction. This study was designed to investigate the potential therapeutic ...
BRAIN - TRAUMATIC BRAIN INJURY

Molecular hydrogen in drinking water protects against neurodegenerative changes induced by traumatic ...

Year Published: 2014

Traumatic brain injury (TBI) in its various forms has emerged as a major problem for modern society. Acute TBI can transform into a chronic condition and be a risk factor for neurodegenerative diseases such as Alzheimer's and Parkinson's diseases, probably through induction of oxidative stress and neuroinflammation. Here, we examined the ability of the antioxidant molecular hydrogen given in ...
BRAIN - AMYOTROPHIC LATERIAL SCLEROSIS

Treatment with Hydrogen-Rich Saline Delays Disease Progression in a Mouse Model of Amyotrophic ...

Year Published: 2015

Amyotrophic lateral sclerosis (ALS) is the most frequent adult-onset motor neuron disease, and accumulating evidence indicates that oxidative mechanisms contribute to ALS pathology, but classical antioxidants have not performed well in clinical trials. The aim of this work was to investigate the effect of treatment with hydrogen molecule on the development of disease in mutant SOD1 G93A transgenic ...
BRAIN - STROKE

Role of FOXO3A in process of hydrogen-rich saline attenuating global cerebral ischemia-reperfusion ...

Year Published: 2015

To investigate the role of FOXO3a in process of hydrogen-rich saline attenuating global cerebral ischemia-reperfusion (I/R) injury in rats. Seventy-two male Sprague Dawley rats, weighing 280-320 g, were randomly divided into six groups (n = 12 each) : sham operation group (group I), cerebral ischemia-reperfusion group (group II), hydrogen-rich saline group (group III), vehicle group (group IV), ...
BRAIN - TRAUMATIC BRAIN INJURY

Effects of hydrogen rich water on the expression of Nrf 2 and the oxidative stress in rats with ...

Year Published: 2015

Objective: To investigate the effects of hydrogen rich water on the expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and oxidative stress in rats with traumatic brain injury (TBI). Methods: Ninety healthy male Sprague-Dawley (SD) rats were randomly divided into sham operation group, TBI group and hydrogen rich water treatment group (HW group), with 30 rats in each group. TBI model ...
BRAIN - DIABETES

Protective effect of hydrogen‑rich medium against high glucose‑induced apoptosis of Schwann ...

Year Published: 2015

Diabetic peripheral neuropathy (DPN) is considered to be one of the most prevalent and life threatening microvascular diabetic complications. DPN affects up to 50% of patients with diabetes mellitus and there are currently no efficacious therapeutic strategies available for its treatment. Previous studies have reported that oxidative stress and poly(ADP‑ribose) polymerase‑1 (PARP‑1) may be ...
BRAIN - SURGERY/TRANSPLANTATION

Hydrogen Suppresses Hypoxia/Reoxygenation-Induced Cell Death in Hippocampal Neurons Through Reducing ...

Year Published: 2015

Deep hypothermic circulatory arrest (DHCA) is a cerebral protection technique that has been used in the operations involving the aortic arch and brain aneurysm for decades. We previous showed that DHCA treated rats developed a significant oxidative stress and apoptosis in neurons. We here intend to investigate the protective the effect of hydrogen against oxidative stress-induced cell injury and ...
BRAIN - TRAUMATIC BRAIN INJURY

Hydrogen-rich water attenuates brain damage and inflammation after traumatic brain injury in rats

Year Published: 2015

Inflammation and oxidative stress are the two major causes of apoptosis after traumatic brain injury (TBI). Most previous studies of the neuroprotective effects of hydrogen-rich water on TBI primarily focused on antioxidant effects. The present study investigated whether hydrogen-rich water (HRW) could attenuate brain damage and inflammation after traumatic brain injury in rats. A TBI model was ...
BRAIN - STROKE

Hydrogen improves neurological function through attenuation of blood–brain barrier disruption in ...

Year Published: 2015

Enhanced oxidative stress occurs in spontaneously hypertensive stroke-prone rats (SHRSP), and is important in blood-brain barrier (BBB) disruption. Hydrogen can exert potent protective cellular effects via reduction in oxidative stress in various diseases. The present study investigated whether long-term hydrogen treatment can improve neurological function outcome in the SHRSP model, and the ...