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Studies Found: 23

PREGNANCY - GUT MICROBIOME

Fructooligosaccharide feeding during gestation to pregnant mice provided excessive folic acid ...

Year Published: 2023

Fructooligosaccharide (FOS) is fermented by intestinal microbes to generate intestinal microbe-derived hydrogen gas (IMDH). Oxidative stress increases during gestation, whereas hydrogen gas has antioxidant effects with therapeutic benefits. We have previously reported that the offspring from a pregnant, excessive folic acid mouse model (PEFAM) had abnormal glucose metabolism after growth. We ...
PREGNANCY - PREECLAMPSIA

Hydrogen suppresses oxidative stress by inhibiting the p38 MAPK signaling pathway in preeclampsia

Year Published: 2022

Background: Hypertensive disorders complicating pregnancy (HDCP) are one of the most serious medical disorders during pregnancy. Objectives: To investigate the effects of hydrogen on the mitogen-activated protein kinase (MAPK) signaling pathway in preeclampsia (PE). Material and methods: The N(omega)-nitro-L-arginine methyl ester (L-NAME)-induced PE model with Sprague Dawley (SD) rats was ...
PREGNANCY - IMMUNE REGULATION

Molecular hydrogen has a positive impact on pregnancy maintenance through enhancement of ...

Year Published: 2022

Aims: Molecular hydrogen (H2) has attracted growing interest because of its implications in various diseases. However, the molecular mechanisms underlying the remarkable effect of a small amount of H2 remain elusive. No knowledge has been available on the role of H2 in the etiology of pregnancy disorders or its direct influence on human immune cells. Since maternal immunity, T cells in particular, ...
PREGNANCY - NEUROPROTECTION

Social Communication of Maternal Immune Activation-Affected Offspring Is Improved by Si-Based ...

Year Published: 2022

Maternal immune activation (MIA) is triggered by infection or autoimmune predisposition during pregnancy, and cytokines produced by MIA are transmitted through the placenta to the fetal brain, implicating at the onset risks and vulnerability for developmental and psychiatric disorders, such as autism spectrum disorder (ASD) and schizophrenia. To address these kinds of problem in child health, we ...
PREGNANCY - ENVIRONMENTAL POLLUTION

Prenatal Molecular Hydrogen Administration Ameliorates Several Findings in Nitrofen-Induced ...

Year Published: 2021

Oxidative stress plays a pathological role in pulmonary hypoplasia and pulmonary hypertension in congenital diaphragmatic hernia (CDH). This study investigated the effect of molecular hydrogen (H2), an antioxidant, on CDH pathology induced by nitrofen. Sprague-Dawley rats were divided into three groups: control, CDH, and CDH + hydrogen-rich water (HW). Pregnant dams of CDH + HW pups were orally ...
PREGNANCY - OFFSPRING DEVELOPMENT

Effect of alkaline ionized water on reproduction in gestational and lactational rats

Year Published: 1995

Alkaline ionized water (AKW) produced by electrolysis was given to gestational and lactational rats, and its effect on dams, growth of fetuses and offsprings were investigated. The results showed that the intake of food and water in dams increased significantly when AKW was given from the latter half of the gestation period and from the former half of the lactation period. Body weight of the ...
PREGNANCY - MILK PRODUCTION

Influences of alkaline ionized water on milk yield, body weight of offspring and perinatal dam in ...

Year Published: 1999

The authors previously reported that male offspring of mothers rats given alkaline ionized water (AKW) showed a significantly higher body weight by day 14 after birth than did offspring of mother rats given tap water (TPW); furthermore, marked myocardial necrosis and fibrosis were observed particularly in the former male offspring at the age of 15 weeks. In the present experiment we looked for ...
PREGNANCY - MILK PRODUCTION

Influences of alkaline ionized water on milk electrolyte concentrations in maternal rats

Year Published: 2001

We previously reported that body weight on day 14 after birth in male offspring of rats given alkaline ionized water (AKW) was significantly heavier than that in offspring of rats given tap water (TPW), but no significant difference was noted in milk yield and in suckled milk volume between the two groups. Additionally, the offspring in the AKW group and TPW group were given AKW and TPW, ...
PREGNANCY - PREECLAMPSIA

Protective effects of hydrogen-rich saline in preeclampsia rat model

Year Published: 2011

Hydrogen has been reported as a novel antioxidant to selectively reduce levels of toxic reactive-oxygen species (ROS). We investigated the effects of hydrogen-rich saline on the prevention of oxidative injuries in N(omega)-nitro-L-arginine methyl ester (L-NAME) induced rat model of preeclampsia (PE). Sprague-Dawley rats (n = 50) were randomized into five groups: non-pregnant; normal pregnancy; ...
PREGNANCY - NEUROPROTECTION

Protective Effects of Hydrogen on Fetal Brain Injury During Maternal Hypoxia

Year Published: 2011

This study aimed to investigate the effects of hydrogen on fetal brain injury during maternal hypoxia. Pregnant rats (n=12, at gestational day 17) were randomly assigned into three groups; air, hypoxia, and hypoxia plus hydrogen groups were put into a chamber and flushed with room air (21% O2 and 79% N2), hypoxia (8% O2 and 92% N2), and hypoxia with hydrogen mixture (2% H2, 8% O2 and 90% N2), ...
PREGNANCY - PREECLAMPSIA

Regulative effect of hydrogen on oxidative stress level of placental ischemia-reperfusion cell model ...

Year Published: 2014

Objective To investigate the effects of hydrogen on cell protection of placental ischemia-reperfusion cell model of preeclampsia and its possible mechanism. Methods JAR cells cultured in vitro were divided into five groups, i.e. the blank control group, saturated hydrogen group under normal oxygen cultivation conditions (normal oxygen+H2 group), ischemia-reperfusion model group (model group), ...
PREGNANCY - NEUROPROTECTION

Maternal molecular hydrogen administration ameliorates rat fetal hippocampal damage caused by in ...

Year Published: 2014

Molecular hydrogen (H2) scavenges hydroxyl radicals. Recently, H2 has been reported to prevent a variety of diseases associated with oxidative stress in model systems and in humans. Here, we studied the effects of H2 on rat fetal hippocampal damage caused by ischemia and reperfusion (IR) on day 16 of pregnancy with the transient occlusion of the bilateral utero-ovarian arteries. Starting 2 days ...
PREGNANCY - NEUROPROTECTION

Maternal molecular hydrogen administration on lipopolysaccharide-induced mouse fetal brain injury

Year Published: 2015

Fetal brain injury is often related to prenatal inflammation; however, there is a lack of effective therapy. Recently, molecular hydrogen (H2), a specific antioxidant to hydroxyl radical and peroxynitrite, has been reported to have anti-inflammatory properties. The aim of this study was to investigate whether maternal H2 administration could protect the fetal brain against inflammation. Pregnant ...
PREGNANCY - PRETERM BIRTH

Maternal molecular hydrogen treatment attenuates lipopolysaccharide-induced rat fetal lung injury

Year Published: 2015

Maternal inflammation is associated with spontaneous preterm birth and respiratory impairment among premature infants. Recently, molecular hydrogen (H2) has been reported to have a suppressive effect on oxidative stress and inflammation. The aim of this study was to evaluate the effects of H2 on fetal lung injury caused by maternal inflammation. Cell viability and the production of interleukin-6 ...
PREGNANCY - PREECLAMPSIA

Effects of vitamin C, vitamin E, and molecular hydrogen on the placental function in trophoblast ...

Year Published: 2015

Aim: This study aimed to investigate the effects of three different antioxidants, namely vitamin C, vitamin E, and molecular hydrogen, on cytotrophoblasts in vitro. Methods: Two trophoblast cell lines, JAR and JEG-3, were exposed to different concentrations of vitamin C (0, 25, 50, 100, 500, 1,000, 5,000 μmol/L), vitamin E (0, 25, 50, 100, 500, 1,000, 5,000 μmol/L), and molecular hydrogen (0, ...
PREGNANCY - PREECLAMPSIA

Molecular hydrogen ameliorates several characteristics of preeclampsia in the Reduced Uterine ...

Year Published: 2016

Oxidative stress plays an important role in the pathogenesis of preeclampsia. Recently, molecular hydrogen (H2) has been shown to have therapeutic potential in various oxidative stress-related diseases. The aim of this study is to investigate the effect of H2 on preeclampsia. We used the reduced utero-placental perfusion pressure (RUPP) rat model, which has been widely used as a model of ...
PREGNANCY - NEUROPROTECTION

Neuroprotective potential of molecular hydrogen against perinatal brain injury via suppression of ...

Year Published: 2016

Exposure to inflammation in utero is related to perinatal brain injury, which is itself associated with high rates of long-term morbidity and mortality in children. Novel therapeutic interventions during the perinatal period are required to prevent inflammation, but its pathogenesis is incompletely understood. Activated microglia are known to play a central role in brain injury by producing a ...
PREGNANCY - HIGH BLOOD PRESSURE

Hydrogen inhibits cytotrophoblast cells apoptosis in hypertensive disorders complicating pregnancy

Year Published: 2016

Hypertensive disorders complicating pregnancy (HDCP) is one of the most serious medical disorders during pregnancy. Hydrogen is a therapeutic antioxidant and used to treat HDCP effectively. However, the molecular mechanism about the effect of hydrogen on HDCP still remains unclear. In this study, we found ROS content in HDCP group was significantly higher than that in the control and was reduced ...
PREGNANCY - DEHYDRATION

Hydrogen-rich water ameliorates rat placental stress induced by water restriction

Year Published: 2018

Dehydration is one of the intrauterine abnormalities that could lead to fetal growth retardation and to increase the risk of a variety of adult diseases later in life. This study were to determine the impact of hydrogen-rich water (HRW) supplementation on placental angiotensin II type 1 receptor and placental oxidative stress induced by water restriction. Pregnant Wistar rat were randomly assigned ...
PREGNANCY - PERIODONTITIS/PLAQUE/GINGIVITIS

Hydrogen rich water attenuates pregnancy gingivitis induced by ligation in SD rats

Year Published: 2018

Purpose: To investigate the effect of hydrogen rich water on experimental gingivitis in SD rats during pregnancy. Methods: Female SD rats mated with male ones were chosen to induce experimental gingivitis after ligation for 2 weeks. The pregnant rats were randomly divided into control group, model group and HW group. In the control and model group, rats were given pure water, while animals in the ...
PREGNANCY - PRETERM BIRTH

Effect of molecular hydrogen on uterine inflammation during preterm labour

Year Published: 2018

Intrauterine inflammation causes preterm birth and is associated with complications in preterm neonates. Thus, strategies aimed at suppressing inflammation are expected to be effective for reducing the risk of preterm birth and associated complications. Our previous studies demonstrated that molecular hydrogen (H2), an anti-inflammatory agent, prevented inflammation-induced impairment in foetal ...
PREGNANCY - NEUROPROTECTION

Administration of molecular hydrogen during pregnancy improves behavioral abnormalities of offspring ...

Year Published: 2018

The aim of the present study was to investigate long-term outcomes of the offspring in a lipopolysaccharide (LPS)-induced maternal immune activation (MIA) model and the effect of maternal molecular hydrogen (H2) administration. We have previously demonstrated in the MIA mouse model that maternal administration of H2 attenuates oxidative damage and neuroinflammation, including induced ...
PREGNANCY - OFFSPRING DEVELOPMENT

Effect of ionised (electrolysed) water on the rat embryo development

Year Published: 2020

The aim of this study was to investigate the effects ionised water has on embryonic development using Wistar rat animal model. For that purpose, alkaline and acidic water was prepared with a domestic water ioniser. It was found that the concentrations of Cl–, SO42– ions increased in acidic water, while in alkaline water, Ca2+ concentration decreased and halogenated hydrocarbon concentrations ...