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Studies Found: 256

BRAIN - ALZHEIMER'S DISEASE

Sustained release of bioactive hydrogen by Pd hydride nanoparticles overcomes Alzheimer’s ...

Year Published: 2019

Oxidative stress-induced mitochondrial dysfunction plays an important role in the pathogenesis of Alzheimer's disease (AD). Hydrogen molecule, a special antioxidant, can selectively scavenge highly cytotoxic reactive oxygen species such as ·OH, exhibiting a potential to treat AD by reducing oxidative stress. However, there is no effective route to realize the continuous and efficient accumulation ...
SPINE - SPINAL CORD INJURY

Inhalation of Hydrogen of Different Concentrations Ameliorates Spinal Cord Injury in Mice by ...

Year Published: 2018

Background/aims: Hydrogen selectively neutralizes reactive oxygen species (ROS) and ameliorates various ROS-induced injuries. Spinal cord injury (SCI) is a serious injury to the central nervous system, and secondary SCI is closely related to excessive ROS generation. We hypothesized that hydrogen inhalation ameliorates SCI, and the mechanism of action may be related to the protective effects of ...
BRAIN - STROKE

Neuroprotective effects of hydrogen inhalation in an experimental rat intracerebral hemorrhage model

Year Published: 2018

Objective: Hydrogen inhalation has been found to be neuroprotective and anti-oxidative in several brain injury models. Building on these studies, we investigated potential neuroprotective effects of hydrogen inhalation in a rat model of intracerebral hemorrhage (ICH), focusing on apoptosis and inflammation. Methods: Forty-five 8-week-old male Sprague-Dawley rats were randomly divided into three ...
BRAIN - TRAUMATIC BRAIN INJURY

Effect of hydrogen-rich water on the chondriosome damage and cytokines in brain tissue of rats with ...

Year Published: 2018

Objective: To observe the effect of hydrogen-rich water on the chondriosome damage and cytokines change in brain tissue of rats with traumatic brain injury (TBI). Methods: Fifty-four health male Sprague-Dawley (SD) rats were divided into three groups by random number table: sham group, trauma group (TBI group), and trauma+hydrogen-rich water group (TBI+HW group), the rats in each group were ...
BRAIN - AUTISM SPECTRUM DISORDER

Hydrogen-Rich Water Ameliorates Autistic-Like Behavioral Abnormalities in Valproic Acid-Treated ...

Year Published: 2018

Due to its anti-inflammatory and anti-oxidative effects, recent research has demonstrated that molecular hydrogen can serve as a new medical approach for depression, anxiety and traumatic brain injury. However, its potential effects on neurodevelopmental diseases, such as autism are still elusive. The present study aims to investigate the potential effects of hydrogen-rich water (HRW) ...
BRAIN - ALZHEIMER'S DISEASE

Hydrogen-rich water improves cognitive impairment gender-dependently in APP/PS1 mice without ...

Year Published: 2018

Alzheimer's disease (AD) is characterised as a provoked inflammatory response and oxidative stress along with amyloid β peptide (Aβ) deposition and neurofibrillary tangles in the brain, and effective treatment is greatly needed. Molecular hydrogen, which has been proposed to be an antioxidant that selectively reduces reactive oxygen species, was found to exert beneficial effects in Aβ ...
BRAIN - STROKE

Hydrogen inhalation improves mouse neurological outcomes after cerebral ischemia/reperfusion ...

Year Published: 2018

This study aimed to investigate the role of necroptosis in the neuroprotection of hydrogen in a mouse model of cerebral ischemia/reperfusion (I/R) injury. C57BL mice were randomly divided into sham group, I/R group, hydrogen/oxygen group (HO), nitrogen/oxygen group (NO). Middle cerebral artery occlusion (MCAO) for 1 hour followed by reperfusion was introduced to animals which were allowed to ...
BRAIN - CARDIOPULMONARY RESUSCITATION (CPR)

Inhalation of high concentration hydrogen gas improves short-term outcomes in a rat model of ...

Year Published: 2018

Cardiogenic global brain hypoxia-ischemia is a devastating medical problem that is associated with unfavorable neurologic outcomes. Low dose hydrogen gas (up to 2.9%) has been shown to be neuroprotective in a variety of brain diseases. In the present study, we investigated the protective effect of water by electrolysis-derived high concentration hydrogen gas (60%) in a rat model of asphyxia ...
PREGNANCY - NEUROPROTECTION

Administration of molecular hydrogen during pregnancy improves behavioral abnormalities of offspring ...

Year Published: 2018

The aim of the present study was to investigate long-term outcomes of the offspring in a lipopolysaccharide (LPS)-induced maternal immune activation (MIA) model and the effect of maternal molecular hydrogen (H2) administration. We have previously demonstrated in the MIA mouse model that maternal administration of H2 attenuates oxidative damage and neuroinflammation, including induced ...
BRAIN - DIABETES

Hydrogen‑rich medium alleviates high glucose‑induced oxidative stress and parthanatos in rat ...

Year Published: 2018

Diabetic peripheral neuropathy (DPN) is considered to be the most common cause of microvascular diabetic complications, for which no effective therapies currently exist. Previous studies have identified that oxidative stress is the common pathway in all possible hypotheses for the induction of DPN, and poly(ADP‑ribose) (PAR) polymerase‑1 (PARP‑1)‑dependent cell death (parthanatos) is key ...
BRAIN - SLEEP APNEA

Hydrogen ameliorates chronic intermittent hypoxia-induced neurocognitive impairment via inhibiting ...

Year Published: 2018

Obstructive sleep apnea (OSA) is a very common breathing and sleep disorder characterized by intermittent hypoxia (IH), which is often associated with behavioral and neurocognitive functions impairment. Hydrogen (H2), as a novel and effective antioxidant, is reported to be a potential neuroprotective agent. The aim of this study is to investigate whether H2 could improve CIH-induced neurocognitive ...
BRAIN - MULTIPLE SCLEROSIS

Hydrogen-Rich Saline Ameliorates Experimental Autoimmune Encephalomyelitis in C57BL/6 Mice Via the ...

Year Published: 2018

Multiple sclerosis (MS) is a chronic and inflammatory disease of the central nervous system that is associated with demyelination, neurodegeneration, and sensitivity to oxidative stress. Hydrogen-rich saline (HRS) is efficacious in preventive and therapeutic applications for many disorders because of its antioxidant and anti-inflammatory properties. Here, we determined the effect of HRS in ...
BRAIN - STROKE

Effects of hydrogen on polarization of macrophages and microglia in a stroke model

Year Published: 2018

It has been confirmed that inflammation plays an important role in the pathogenesis of ischemic stroke. The polarization of microglia as an important participant in the inflammation following stroke is also found to be involved in stroke. This study aimed to investigate the effects of hydrogen gas on the polarization of macrophages/microglia in vitro. Raw264.7 cells were treated with ...
BRAIN - DEMENTIA

Effects of Molecular Hydrogen Assessed by an Animal Model and a Randomized Clinical Study on Mild ...

Year Published: 2018

Background: Oxidative stress is one of the causative factors in the pathogenesis of neurodegenerative diseases including mild cognitive impairment (MCI) and dementia. We previously reported that molecular hydrogen (H2) acts as a therapeutic and preventive antioxidant. Objective: We assess the effects of drinking H2-water (water infused with H2) on oxidative stress model mice and subjects with MCI. ...
BRAIN - TRAUMATIC BRAIN INJURY

Molecular Hydrogen Prevents Social Deficits and Depression-Like Behaviors Induced by Low-Intensity ...

Year Published: 2018

Detonation of explosive devices creates blast waves, which can injure brains even in the absence of external injuries. Among these, blast-induced mild traumatic brain injury (bmTBI) is increasing in military populations, such as in the wars in Afghanistan, Iraq, and Syria. Although the clinical presentation of bmTBI is not precisely defined, it is frequently associated with psycho-neurological ...
BRAIN - NEUROPROTECTION

Hydrogenized Water Effects on Protection of Brain Cells from Oxidative Stress and Glutamate Toxicity

Year Published: 2018

Hydrogenized water is known to have protective effects on cells and tissues, mainly through its antioxidant activities. Here we examined the protective effects of a commercial source of hydrogenized water on cultured human brain cells. Hydrogenized water was able to protect brain cells from oxidative stress and glutamate toxicity. At H 2 concentrations above 0.01 mM the glutathione levels ...
BRAIN - BRAIN INJURY

Molecular hydrogen alleviates asphyxia-induced neuronal cyclooxygenase-2 expression in newborn pigs

Year Published: 2018

Cyclooxygenase-2 (COX-2) has an established role in the pathogenesis of hypoxic-ischemic encephalopathy (HIE). In this study we sought to determine whether COX-2 was induced by asphyxia in newborn pigs, and whether neuronal COX-2 levels were affected by H2 treatment. Piglets were subjected to either 8 min of asphyxia or a more severe 20 min of asphyxia followed by H2 treatment (inhaling room air ...
BRAIN - NEUROPATHIC PAIN

Hydrogen-Rich Saline Activated Autophagy via HIF-1 α Pathways in Neuropathic Pain Model

Year Published: 2018

Background Neuropathic pain is a chronic and intractable pain, with very few effective analgesics. It involves an impaired cell autophagy process. Hydrogen-rich saline (HRS) reportedly reduces allodynia and hyperalgesia in a neuropathic pain model; however, it is unknown whether these effects involve autophagy induction. Methods We investigated the relationship between HRS and cell autophagy in a ...
BRAIN - TRAUMATIC BRAIN INJURY

Hydrogen Gas Treatment Improves the Neurological Outcome After Traumatic Brain Injury Via Increasing ...

Year Published: 2018

Hydrogen gas (H2) exerts a beneficial effect against traumatic brain injury (TBI). microRNA-21 (miR-21) is one of the most highly expressed members of small non-coding microRNA family in mammalian cells. miR-21 can improve the neurological outcome after TBI. In the present study, we investigated whether H2 treatment could improve the neurological outcome after TBI via increasing miR-21 expression. ...
EYE - RETINAL INJURY

Hydrogen postconditioning promotes survival of rat retinal ganglion cells against ...

Year Published: 2018

Retinal ischemia/reperfusion injury (IRI) plays a crucial role in the pathophysiology of various ocular diseases. Our previous study have shown that postconditioning with inhaled hydrogen (H2) (HPC) can protect retinal ganglion cells (RGCs) in a rat model of retinal IRI. Our further study aims to investigate potential mechanisms underlying HPC-induced protection. Retinal IRI was performed on the ...
BRAIN - STROKE

Hydrogen exerts neuroprotective effects on OGD/R damaged neurons in rat hippocampal by protecting ...

Year Published: 2018

Cerebral ischemia/reperfusion injury (IRI) is a serious complication during the treatment of stroke patients with very few effective clinical treatment. Hydrogen (H2) can protect mitochondria function and have favorable therapeutic effects on cerebral IRI. Mitophagy plays an important role in eliminating damaged or dysfunctional mitochondria and maintaining mitochondria homeostasis. However, ...
BRAIN - TRAUMATIC BRAIN INJURY

Hydrogen-rich water attenuates oxidative stress in rats with traumatic brain injury via Nrf2 pathway

Year Published: 2018

Background: Several studies have recently found that oxidative stress plays a pivotal role in the pathogenesis of traumatic brain injury (TBI) and may represent a target in TBI treatment. Hydrogen-rich water was recently shown to exert neuroprotective effects in various neurological diseases through its antioxidant properties. However, the mechanisms underlying its effects in TBI are not clearly ...
BRAIN - NEUROPROTECTION

Effects of hydrogen-rich water on attenuating fatigue induced by daily activities or mental tasks

Year Published: 2018

Objectives In 2007, the first report that hydrogen removes active oxygen was published, and many clinical and non-clinical studies have since been conducted using hydrogen gas or water. Several diseases and symptoms are related to active oxygen, and fatigue is also induced by increases in oxidative stress. The current randomized, double-blind, placebo-controlled, crossover study was conducted to ...
WHOLE BODY - NEUROPROTECTION

Structural and lipid peroxidation effects of lead on rat hippocampus and its attenuation by hydrogen ...

Year Published: 2018

Despite the well-known toxicity and the efforts to control its exposure, lead still has a serious health concern, particularly in young ages. Chelation therapy cannot correct the neurocognitive effects of chronic exposure. So, there is a requirement to test different protective agents for lead intoxication. Hydrogen-rich water (HRW) has gained attraction recently as an antioxidant. Four groups of ...
BRAIN - CARDIOPULMONARY RESUSCITATION (CPR)

Hydrogen Inhalation is Superior to Mild Hypothermia for Improving Neurological Outcome and Survival ...

Year Published: 2017

Background: Postcardiac arrest syndrome is the consequence of whole-body ischemia-reperfusion events that lead to multiple organ failure and eventually to death. Recent animal studies demonstrated that inhalation of hydrogen greatly mitigates postresuscitation myocardial dysfunction and brain injury. However, the influence of underlying heart disease on the efficacy of hydrogen is still unknown. ...