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Studies Found: 1250

MOUTH - CANCER

Acid-electrolyzed functional water-induces Interleukin-1╬▒ release from Intracellular Storage Sites ...

Year Published: 2021

The aim of this study was to examine the acid-electrolyzed functional water (FW)-mediated cytokine release in an oral squamous cell carcinoma-derived cell line (OSCC) following treatment with FW. FW is generated by the electrolysis of a sodium chloride solution and accelerate the burn wound healing. To elucidate the underlying mechanisms, the cytokine/chemokine secretion profile of HSC3 cells was ...
BRAIN - STROKE

Intravenous Hydrogen Therapy With Intracisternal Magnesium Sulfate Infusion in Severe Aneurysmal ...

Year Published: 2021

Background and purpose: Poor-grade subarachnoid hemorrhage still has a poor prognosis. This randomized controlled clinical trial evaluated intracisternal magnesium sulfate infusion combined with intravenous hydrogen therapy in patients with poor-grade subarachnoid hemorrhage. Methods: Thirty-seven patients with poor-grade subarachnoid hemorrhage were randomized to Mg+H2, Mg, and control groups. Mg ...
BRAIN - PARKINSON'S DISEASE

Effects of concomitant use of hydrogen water and photobiomodulation on Parkinson disease: A pilot ...

Year Published: 2021

Background: Parkinson disease (PD), the second most common neurodegenerative disease, has no cure or applicable disease-modifying approach, only symptomatic therapy. Oxidative stress and mitochondrial dysfunction play key roles in PD pathophysiology. Animal studies have demonstrated that photobiomodulation (PBM) may enhance mitochondrial function and boost adenosine triphosphate production, thus ...
MUSCLE - SURGERY/TRANSPLANTATION

Protective Effect of Hydrogen Gas on Mice Hind Limb Ischemia-Reperfusion Injury

Year Published: 2021

Background: The aim of this study was to investigate the mechanism of hydrogen gas on hind limb IR injury. Methods: Male C57BL/6 mice were randomly divided into three groups: sham group (Sham), ischemia-reperfusion group (IR), IR plus H2 inhalation group (IR + H2). IR was induced by interrupting hind limb blood flow for 3h, followed by 4h of reperfusion, and H2 was administered by inhalation ...
LIVER - CANCER

In vivo X-ray triggered catalysis of H2 generation for cancer synergistic gas-radiotherapy

Year Published: 2021

To date, hydrogen (H2) therapy has received widespread attention. However, X-ray triggered sustainable H2-producing materials with controlled release for cancer treatment have not been reported. Herein, an X-ray triggered sustainable in situ H2 producing platform, Au NR-TiO2@ZnS:Cu,Co-A(Au-TiO2@ZnS), composed of Au-amorphous TiO2 nano-dumbbell-shaped heterostructure coated with long afterglow ...
WHOLE BODY - OBESITY

Hydrogen Nano-Bubble Water Suppresses ROS Generation, Adipogenesis, and Interleukin-6 Secretion in ...

Year Published: 2021

Reactive oxygen species (ROS)-induced oxidative stress in adipose tissue is associated with inflammation and the development of obesity-related metabolic disorders. The aim of this study is to investigate the effects of hydrogen nano-bubble water (HW) on ROS generation, adipogenesis, and interleukin-6 (IL-6) secretion in hydrogen peroxide (H2O2) or phorbol 12-myristate 13-acetate (PMA)-stimulated ...
BONE - RHEUMATOID ARTHRITIS (RA)

Magnesium-Based Micromotors as Hydrogen Generators for Precise Rheumatoid Arthritis Therapy

Year Published: 2021

Hydrogen therapy is an emerging and highly promising strategy for the treatment of inflammation-related diseases. However, nonpolarity and low solubility of hydrogen under the physiological conditions results in a limited therapeutic effect. Herein, we develop a biocompatible magnesium micromotor coated with hyaluronic acid as a hydrogen generator for precise rheumatoid arthritis management. The ...
BRAIN - SEPSIS

Hydrogen gas alleviates sepsis-induced neuroinflammation and cognitive impairment through regulation ...

Year Published: 2021

Sepsis-associated encephalopathy (SAE) can cause acute and long-term cognitive impairment and increase the mortality rate in sepsis patients, and we previously reported that 2% hydrogen gas (H2) inhalation has a therapeutic effect on SAE, but the underlying mechanism remains unclear. Dynamic DNA methylation, which catalyzed by DNA methyltransferases (DNMTs), is involved in the formation of ...
LUNG - ASTHMA

Molecular hydrogen alleviates asthma through inhibiting IL-33/ILC2 axis

Year Published: 2021

Background: Asthma is one of the most common noninfectious chronic diseases characterized by type II inflammation. This study aimed to investigate the effects of molecular hydrogen on the pathogenesis of asthma. Methods: OVA sensitized asthma mouse model and house dust mite treated 16HBE cellular model were established and hydrogen/oxygen mixture was used to treat asthmatic mice and 16HBE cells. ...
LIVER - LIVER DISEASE

Hydrogen gas alleviates acute alcohol-induced liver injury by inhibiting JNK activation

Year Published: 2021

Binge alcohol drinking is fast becoming a global health concern, with the liver among the first organ involved and the one afflicted with the greatest degree of injury. Oxidative stress, alterations in hepatic metabolism, immunity and inflammation have all been reported to contribute to the development of alcoholic liver disease (ALD). Hydrogen gas (H2) serves a key role in the modulation of ...
BRAIN - PARKINSON'S DISEASE

Hydrogen-saturated saline mediated neuroprotection through autophagy via PI3K/AKT/mTOR pathway in ...

Year Published: 2021

Some cardiovascular symptoms in the early stage of Parkinson's disease (PD) were related to degeneration of the rostral ventrolateral medulla (RVLM) catecholaminergic neurons. To date, little is known about the effects of hydrogen water on early stage of PD. Here, protective actions of hydrogen-saturated saline (HS) on rotenone-induced PD rats, as well as its underlying mechanisms were ...
WHOLE BODY - DIABETES (TYPE II)

The protective effect of hydrogen-rich water on rats with type 2 diabetes mellitus

Year Published: 2021

The hydrogen-rich water (HW) has been reported to possess a beneficial role in patients with diabetes. However, a systemic evaluation with an appropriate animal model is necessary to reveal its mechanisms and efficacy. Herein, the protective effects of drinking HW on lipid and glucose metabolism, oxidative stress, and inflammation in type 2 diabetes mellitus (T2DM) rats were investigated. The ...
LUNG - CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD)

Hydrogen/oxygen therapy for the treatment of an acute exacerbation of chronic obstructive pulmonary ...

Year Published: 2021

Background: To investigate whether the administration of hydrogen/oxygen mixture was superior to oxygen in improving symptoms in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods: This prospective, randomized, double-blind, controlled clinical trial in 10 centres enrolled patient with AECOPD and a Breathlessness, Cough, and Sputum Scale (BCSS) score of at ...
STOMACH - CANCER

Hydrogen inhibits the proliferation and migration of gastric cancer cells by modulating lncRNA ...

Year Published: 2021

Background: Gastric cancer is one of the most prevalent and deadly malignancies without efficient treatment option. This study aimed to investigate the effect of hydrogen gas on the behavior of gastric cancer cells. Methods: Gastric cancer cell lines MGC-803 and BGC-823 were treated with or without H2 /O2 gas mixture (66.7%:33.3% v/v). Proliferation and migration were assessed by MTT and scratch ...
STOMACH - GASTRIC MUCOSAL INJURY

Metal-Organic Framework Based Hydrogen Release Platform for Multi-Effective Helicobacter Pylori ...

Year Published: 2021

Helicobacter pylori (H. pylori) infection is the leading cause of chronic gastritis, peptic ulcer and gastric cancer. Antibiotics, as traditional method for eliminating H. pylori, have no targeting effect, which cause serious bacterial resistance and gut dysbacteriosis. Moreover, antibiotics can hardly address hyperactive inflammatory response or damaged gastric mucosal barrier caused by H. pylori ...
WHOLE BODY - ROS-SCAVENGING

Dependencies of hydrogen-water on mineral-based hardness, temperatures and the container materials, ...

Year Published: 2020

Widely distributed electrolytic-generators for hydrogen-water are not fully considered for the dependencies of post-electrolytic values of the dissolved hydrogen concentration (DH) and the oxidation-reduction potential (ORP) on the properties of the pre-electrolytic water. We investigated the dependencies of DH and ORP on mineral-based hardness, temperatures and the container materials, and ...
WHOLE BODY - EXCERCISE

The Effects of Supersaturated Hydrogen-Rich Water Bathing on Biomarkers of Muscular Damage and ...

Year Published: 2020

High-intensity eccentric exercise can cause a delayed onset of muscle soreness (DOMS), a short-term condition characterized by muscle damage and tenderness that might hold up recovery and jeopardize exercise routine. Previous studies indicated that hydrogen-rich water (HRW) might be a helpful topical intervention to boost recovery in musculoskeletal medicine, yet no data are available concerning ...
MOUTH - PERIODONTITIS

Effects of Electrolyzed Water on the Growth of Oral Pathologic Bacteria Species and its Cytotoxic ...

Year Published: 2020

Background: Microbial plaque-induced oral diseases are among the most common diseases worldwide. The present study aimed to compare the antimicrobial effect of electrolyzed water (EW), (acidic, mildly basic, and basic) on the growth of bacterial species producing dental plaque and to assess their cytotoxicity on fibroblasts and epithelial cells. Methods: The study was performed at Shahid Beheshti ...
HEART - HYPERTENSION

Hydrogen-rich saline mitigates pressure overload-induced cardiac hypertrophy and atrial fibrillation ...

Year Published: 2020

Objective To investigate if hydrogen-rich saline (HRS), which has been shown to have antioxidant and anti-inflammatory properties, could mitigate cardiac remodelling and reduce the incidence of atrial fibrillation (AF) in the rat model of cardiac hypertrophy. Methods Pressure overload was induced in rats by abdominal aortic constriction (AAC). The animals were separated into four groups: sham; AAC ...
BRAIN - BRAIN INJURY

Hydrogen Gas Attenuates Hypoxic-Ischemic Brain Injury via Regulation of the MAPK/HO-1/PGC-1a Pathway ...

Year Published: 2020

Neonatal hypoxic-ischemic encephalopathy (HIE) is a leading cause of death in neonates with no effective treatments. Recent advancements in hydrogen (H2) gas offer a promising therapeutic approach for ischemia reperfusion injury; however, the impact of this approach for HIE remains a subject of debate. We assessed the therapeutic effects of H2 gas on HIE and the underlying molecular mechanisms in ...
LUNG - CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD)

Hydrogen gas (XEN) inhalation ameliorates airway inflammation in asthma and COPD patients

Year Published: 2020

Background: Hydrogen was proven to have anti-oxidative and anti-inflammation effects to various diseases. Aim: We wish to investigate the acute effects of inhaled hydrogen on airway inflammation in patients with asthma and chronic obstructive pulmonary disease (COPD). Design: Prospective study. Methods: 2.4% hydrogen containing steam mixed gas (XEN) was inhaled once for 45 minutes in 10 patients ...
BRAIN - TRAUMATIC BRAIN INJURY

Hydrogen improves cell viability partly through inhibition of autophagy and activation of ...

Year Published: 2020

Objective´╝ÜTraumatic brain injury (TBI) is one of the most serious public health problems in the world. Hydrogen (H2), a flammable, colorless, and odorless gas, has been observed to have preventive and therapeutic effects on brain trauma and other neurological disorders, but its exact mechanism has not been fully clarified. Methods: To further study the mechanism underlying the role of hydrogen ...
BRAIN - ADDICTION

Molecular hydrogen attenuates methamphetamine-induced behavioral sensitization and activation of ...

Year Published: 2020

Methamphetamine (METH) is one of the most prevalently used illegal psychostimulants in many countries. Continuous exposure to METH leads to behavioral sensitization in animals, which can be used as a behavioral model with many mechanisms in common with relapse in humans. Molecular hydrogen has recently gained attention for its potential as a novel healthcare product with preventive and therapeutic ...
KIDNEY - ACUTE KIDNEY INJURY

Saturated hydrogen alleviates CCl 4 -induced acute kidney injury via JAK2/STAT3/p65 signaling

Year Published: 2020

Objectives: This study assessed the protective effects of saturated hydrogen against CCl4-induced acute kidney injury (AKI) in mice, and investigated signaling pathways activated by exposure to saturated hydrogen. Methods: A mouse model of CCl4-induced AKI was established; some mice were treated with saturated hydrogen. Levels of cystatin C and kidney injury molecule 1 were determined using ...
BRAIN - SEPSIS

Hydrogen Gas Alleviates Sepsis-Induced Brain Injury by Improving Mitochondrial Biogenesis Through ...

Year Published: 2020

Sepsis-associated encephalopathy (SAE) affects approximately one-third of septic patients, and there is a lack of effective therapeutics for SAE. Hydrogen gas is a new medical gas that exerts anti-inflammation, antioxidation, and anti-apoptotic effects and can effectively protect septic mice. Mitochondrial dysfunction, which can be improved by mitochondrial biogenesis, is a type of molecular ...