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Studies Found: 1250

BRAIN - SEPSIS

Hydrogen alleviated neuronal injury and neuroinflammation induced by microglial activation via the ...

Year Published: 2021

Objective: Sepsis-associated encephalopathy (SAE) is characterized by diffuse cerebral and central nervous system (CNS) dysfunction. Microglia play a vital role in protecting the brain from neuronal damage, which is closely related to inflammatory responses. The Nrf2 signaling pathway has an impact on microglial and neuronal injury. Here, we mainly explored the molecular mechanism by which H2 ...
WHOLE BODY - AGING

High-flow hydrogen inhalation might suppresses the immune function of middle-aged participants: a ...

Year Published: 2021

Hydrogen inhalation therapy has been proven to be safe and effective in disease treatment in multiple clinical reports, but the gas flow rates used in different studies vary greatly. Since there is no upper limit for the safe concentration of hydrogen, this study tested the effects of high-flow (not high concentration) hydrogen inhalation on immune function. From October 2019 to January 2020, 20 ...
SKIN - COSMETIC ISSUES

Effects of Topical Hydrogen Purification on Skin Parameters and Acne Vulgaris in Adult Women

Year Published: 2021

Background: Acne vulgaris is a prevalent dermatological disease characterized by skin eruptions, which may decrease the sufferer's quality of life. Hydrogen purification treatment is a new procedure used in cosmetology to improve the skin parameters of the face. This study examined the effectiveness of hydrogen purification treatment to improve women's skin conditions with regard to acne vulgaris. ...
HEART - EXCERCISE

Acute hydrogen-rich water ingestion stimulates cardiac autonomic activity in healthy females

Year Published: 2021

Background: Hydrogen-rich water (HRW) has been shown to have a stimulating effect on the human body. Objective: The aim of the study was to assess the influence of acute HRW intake on autonomic cardiac regulation during 50 min of rest sitting. Methods: Fourteen healthy females (age 21.7 ± 1.2 years, body mass 67.8 ± 8.7 kg, height 167 ± 5.5 cm) took part in this double-blind, randomized, ...
PENIS - SURGERY/TRANSPLANTATION

Protective effects of hydrogen rich saline solution on ventral penile mathieu type flap with penile ...

Year Published: 2021

Introduction: Penile tourniquet (Pt) application aims to work in a bloodless field in penile surgery. When the tourniquet is released, reperfusion injury occurs with the resumption of blood flow. Molecular hydrogen can easily attach to biomembranes and enter cytosol, mitochondria and other organelles of the cell and convert the formed OH- to H₂O to prevent cell and tissue damage. Aim: We ...
BONE MARROW - CANCER

Protective effects of hydrogen gas inhalation on radiation-induced bone marrow damage in cancer ...

Year Published: 2021

Although intensity-modulated radiation therapy (IMRT) has been developed as an alternative to conventional radiotherapy, reducing bone marrow damage is limited. Thus, a novel technology is needed to further mitigate IMRT-induced bone marrow damage. Molecular hydrogen (H2) was recently reported as a preventive and therapeutic antioxidant that selectively scavenges hydroxyl radical (·OH) and ...
WHOLE BODY - STRESS RESILIENCE

Alleviation of the chronic stress response attributed to the antioxidant and anti-inflammatory ...

Year Published: 2021

Reactive oxygen species (ROS) are highly reactive and directly attack surrounding biomolecules to deteriorate cellular and tissue functions. Meanwhile, ROS also serve as signaling mediators to upregulate pro-inflammatory cytokine expression via activation of the nuclear factor kappa B signaling pathway, and the increased pro-inflammatory cytokines trigger respiratory burst of inflammatory cells ...
KIDNEY - DIABETES

Hydrogen water therapy in histopathological improvement of diabetic nephropathy on ...

Year Published: 2021

Diabetic nephropathy (DN) is a renal microvascular abnormality resulting from chronic complications of diabetes mellitus (DM). The main cause of DN is a chronic condition of hyperglycemia which induces oxidative stress in the microvascular system and causes progressive renal failure. Hydrogen water (HW) shows potential in reducing ROS, and anti-inflammatory. This study aims to develop HW therapy ...
MOUTH - CANCER

Carcinostatic effects of alkanoyl ascorbate plus platinum nano-colloid and stabilization of the ...

Year Published: 2021

Carcinostatic effects of combined use of ascorbic acid (Asc), 2-O-phospho- or 6-O-palmitoyl ascorbate (Asc2Phos, Asc6Palm) or diverse alkanoyl Asc, and nano-sized platinum-poly(N-vinyl-pyrrolidone) colloid (PVP-Pt; 2-nm diameter) were examined on human esophagus carcinoma-derived cells KYSE70. Cell viability was repressed by 'Asc6Palm + PVP-Pt' mixture more markedly than by Asc6Palm or PVP-Pt ...
WHOLE BODY - STRESS RESILIENCE

Heat-retention effects of hydrogen-rich water bath assessed by thermography for humans

Year Published: 2021

Hydrogen-rich water bath devices are commercially available, but have been scarcely clarified for heat-retention effects. In this study, heat-retention effects of hydrogen-rich water bath were assessed by thermographic clinical trials, which employed twenty-four healthy subjects. The thermograms indicated that, under the same conditions (41 °C, 10-min bathing), hydrogen-rich water bath (hydrogen ...
EYE - DRY EYE

Randomized, crossover clinical efficacy trial in humans and mice on tear secretion promotion and ...

Year Published: 2021

The incidence of dry eye disease is increasing worldwide because of the aging population and increasing use of information technology. Dry eye disease manifests as tear-layer instability and inflammation caused by osmotic hypersensitization in tear fluids; however, to our knowledge, no agent that treats both pathologies simultaneously is available. Molecular hydrogen (H2) is known to be effective ...
PANCREAS - PANCREATITIS

Pre-inhalation of hydrogen-rich gases protect against caerulein-induced mouse acute pancreatitis ...

Year Published: 2021

Background: Acute pancreatitis (AP) lacks targeted prevention and treatment measures. Some key points in the pathogenesis of AP remain unclear, such as early activation of pancreatic enzymes. Several recent reports have shown the protective effect of hydrogen on several AP animal models, and the mechanism is related to antioxidant activity. Heat shock protein 60 (Hsp60) is known to accompany ...
LUNG - LUNG INJURY

Hydrogen Attenuates Endotoxin-Induced Lung Injury by Activating Thioredoxin 1 and Decreasing Tissue ...

Year Published: 2021

Endotoxin-induced lung injury is one of the major causes of death induced by endotoxemia, however, few effective therapeutic options exist. Hydrogen inhalation has recently been shown to be an effective treatment for inflammatory lung injury, but the underlying mechanism is unknown. In the current study we aim to investigate how hydrogen attenuates endotoxin-induced lung injury and provide ...
BRAIN - ADDICTION

Hydrogen enriched saline alleviates morphine tolerance via inhibiting neuroinflammation, GLT-1, GS ...

Year Published: 2021

The development and maintenance of morphine tolerance showed association with neuroinflammation and dysfunction of central glutamatergic system (such as nitration of glutamate transporter). Recent evidence indicated that hydrogen could reduce the levels of neuroinflammation and oxidative stress, but its role in morphine tolerance has not been studied. The rats were intrathecally administered with ...
LIVER - NON-ALCOHOLIC STEATOHEPATITIS (NASH)

Hydrogen-rich water protects liver injury in nonalcoholic steatohepatitis though HO-1 enhancement ...

Year Published: 2021

Nonalcoholic steatohepatitis (NASH) could progress to hepatic fibrosis when absence of effective control. The purpose of our experiment was to investigate the protective effect of drinking water with high concentration of hydrogen in our study named hydrogen rich water (HRW) on mice with non-alcoholic fatty liver disease to elucidate the mechanism underlying the molecular hydrogen therapeutic ...
WHOLE BODY - CANCER

Drinking Hydrogen-Rich Water Alleviates Chemotherapy-Induced Neuropathic Pain Through the Regulation ...

Year Published: 2021

Introduction: Chemotherapy-induced neuropathic pain (CINP) is one of the most common complications of chemotherapeutic drugs which limits the dose and duration of potentially life-saving anticancer treatment and compromises the quality of life of patients. Our previous studies have reported that molecular hydrogen (H2) can be used to prevent and treat various diseases. But the underlying mechanism ...
BONE - OSTEOARTHRITIS (OA)

Hydrogen (H 2) Alleviates Osteoarthritis by Inhibiting Apoptosis and Inflammation via the JNK ...

Year Published: 2021

Background: Osteoarthritis (OA) is a very common condition and leads to joint pain, disability, and price tag all over the world. Pathogenesis of OA is closely related to numerous inflammatory and apoptosis cytokines. Hydrogen (H2) reportedly exhibits a diversity of effects such as anti-apoptotic, anti-inflammatory, and anti-oxidative properties via the JNK pathway. However, it is unknown whether ...
HEART - METABOLIC SYNDROME

Drinking Molecular Hydrogen Water Is Beneficial to Cardiovascular Function in Diet-Induced Obesity ...

Year Published: 2021

Molecular hydrogen (MH) reportedly exerts therapeutic effects against inflammatory diseases as a suppressor of free radical chain reactions. Here, the cardiovascular protective effects of the intake of molecular hydrogen water (MHW) were investigated using high-fat diet-induced obesity (DIO) mice. MHW was prepared using supplier sticks and degassed water as control. MHW intake for 2 weeks did not ...
WHOLE BODY - SEPSIS

Hydrogen Gas Therapy Attenuates Inflammatory Pathway Signaling in Septic Mice

Year Published: 2021

Background: Molecular hydrogen (H2) has been used in clinical cases. However, there are few studies of H2 therapy to treat sepsis, and anti-inflammatory mechanisms of H2 are mostly unknown. We aimed to confirm effects of H2 therapy on sepsis and reveal its therapeutic mechanism via RNA sequencing in multiple organs in septic mice. Methods: Nine-week-old C57BL/6 male mice underwent cecal ligation ...
HEART - SURGERY/TRANSPLANTATION

Hydrogen gas inhalation alleviates myocardial ischemia-reperfusion injury by the inhibition of ...

Year Published: 2021

Aims: Reperfusion therapy is the most common and effective treatment against ischemic heart disease (IHD), but the process inflicts massive ischemia/reperfusion (I/R) injury for which no treatment exists. Notably, reperfusion after ischemia causes ischemia/reperfusion injury (IR injury) and the 'no-reflow' phenomenon seriously affecting the therapeutic effects in clinical practice. The principle ...
KIDNEY - SURGERY/TRANSPLANTATION

Prevention of Chronic Rejection of Marginal Kidney Graft by Using a Hydrogen Gas-Containing ...

Year Published: 2021

In clinical kidney transplantation, the marginal kidney donors are known to develop chronic allograft rejection more frequently than living kidney donors. In our previous study, we have reported that the hydrogen gas-containing organ preservation solution prevented the development of acute injuries in the kidney of the donor after cardiac death by using preclinical miniature pig model. In the ...
KIDNEY - KIDNEY FAILURE

THE USE OF MOLECULAR HYDROGEN IN CORRECTION OF NO-REFLOW SYNDROME IN THE POLYURIC STAGE OF SUBLIMATE ...

Year Published: 2021

Objective - to find out the possibility of using molecular hydrogen in the correction of no-reflow syndrome in the polyuric stage of acute kidney injury 72 hours after the administration of mercuric chloride in rats on a hyposodium diet. The experiments were performed on 60 male white non-linear sexually mature rats weighing 0.16-0.18 kg to study the effect of water loading with saturation with ...
PERITONIUM - SEPSIS

Peritoneal lavage with hydrogen-rich saline can be an effective and practical procedure for acute ...

Year Published: 2021

Purpose: Acute peritonitis has remained a fatal disease despite of recent advances in care and treatment, including antibiotic and anticoagulant treatments. The cause of death is mostly sepsis-induced multiple organ failure. Oxidative stress can play an important role in this situation, but antioxidant therapy to capture any excessive reactive oxygen species has not yet been fully established. ...
WHOLE BODY - CANCER

Combined treatment with dissolved hydrogen molecule and platinum nanocolloid exerts ...

Year Published: 2021

Many studies have shown that redox regulation is an effective therapeutic strategy for different types of cancer. We have previously demonstrated that combined treatment with dissolved hydrogen molecule (H2) and platinum nanocolloid (Pt-nc) has carcinostatic effects and that increased intracellular reactive oxygen species (ROS) levels were closely associated with carcinostatic effects in Ehrlich ...
HEART - ATHEROSCLEROSIS

Effects of hydrogen as adjuvant treatment for unstable angina

Year Published: 2021

Oxidative stress and inflammation are closely related to atherosclerotic cardiovascular disease. It is established that hydrogen has significant protective effects on many diseases as a potential antioxidative and anti-inflammatory agent. The purpose of this study is to evaluate the effect of hydrogen on unstable angina in vitro and in vivo. An atherosclerosis model in vitro was constructed by ...