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Studies Found: 1335

WHOLE BODY - DIABETES

Molecular hydrogen stimulates the gene expression of transcriptional coactivator PGC-1α to enhance ...

Year Published: 2016

We previously reported that molecular hydrogen (H2) acts as a novel antioxidant to exhibit multiple functions. Moreover, long-term drinking of H2-water (water infused with H2) enhanced energy expenditure to improve obesity and diabetes in db/db mice accompanied by the increased expression of fibroblast growth factor 21 (FGF21) by an unknown mechanism. H2 was ingested by drinking of H2-water or by ...
SPINE - INTERVERTEBRAL DISC DEGENERATION

ROS-responsive magnesium-containing microspheres for antioxidative treatment of intervertebral disc ...

Year Published: 2023

Intervertebral disc degeneration (IVDD) is a degenerative disease characterized by lower-back pain, causing disability globally. Antioxidant therapy is currently considered one of the most promising strategies for IVDD treatment, given the crucial role of reactive oxygen species (ROS) in IVDD pathogenesis. Herein, a ROS-responsive magnesium-containing microsphere (Mg@PLPE MS) was constructed for ...
WHOLE BODY - EXCERCISE

Effects of Alkaline-Reduced Water on Exercise-Induced Oxidative Stress and Fatigue in Young Male ...

Year Published: 2022

Regular physical activity confers health benefits and improves the general quality of life. Recently, alkaline-reduced water (ARW) consumption has garnered increasing attention in the field of sports. ARW effectively inhibits the oxidative stress generated in cells during high-intensity exercises; however, whether it exerts similar effects during exhaustive exercises remains unknown. This study ...
WHOLE BODY - DIABETES (TYPE II)

The Effects of Alkaline Reduced Water Administration to the Fasting Blood Glucose Levels in Patients ...

Year Published: 2020

Background: Alkaline reduced water (ARW) is an electrolyzed water with pH>7. It showed an antioxidant and an antidiabetic benefit, but the results still vary. Aim: To investigate the effect of ARW to fasting blood glucose (FBG) and two-hours post prandial glucose (2hPPG) in Indonesian patients with type-2 diabetes mellitus (T2DM). Methods: This was a randomized double blind controlled trial ...
WHOLE BODY - HYDROGEN BIOLOGY

Hydroxyl-radical scavenging activity of hydrogen does not significantly contribute to its biological ...

Year Published: 2021

Since Ohsawa et al. reported a biological antioxidant function of hydrogen in 2007, researchers have now shown it to exert protective effects in a wide range of human and animal disease models. Clinical observations and scientific arguments suggest that a selective scavenging property of H2 cannot adequately explain the beneficial effects of hydrogen. However, there is no experiment challenging ...
INTESTINE - EPITHELIAL DYSFUNCTION

Alkaline Reduced Water Attenuates Oxidative Stress-Induced Mitochondrial Dysfunction and Innate ...

Year Published: 2021

Redox imbalance in intestinal epithelial cells is critical in the early phases of intestinal injury. Dysfunction of the intestinal barrier can result in immunological imbalance and inflammation, thus leading to intestinal syndromes and associated illnesses. Several antioxidants have been discovered to be beneficial in resolving intestinal barrier dysfunction. Of these antioxidants, the effects of ...
WHOLE BODY - HYDROGEN BIOLOGY

Systemic and local effects of long-term exposure to alkaline drinking water in rats

Year Published: 2001

Alkaline conditions in the oral cavity may be caused by a variety of stimuli, including tobacco products, antacids, alkaline drinking water or bicarbonate toothpaste. The effects of alkaline pH on oral mucosa have not been systematically studied. To assess the systemic (organ) and local (oral mucosal) effects of alkalinity, drinking water supplemented with Ca(OH)2 or NaOH, with pH 11.2 or 12 was ...
WHOLE BODY - DIABETES (TYPE II)

Synergistic Effects of Regular Walking and Alkaline Electrolyzed Water on Decreasing Inflammation ...

Year Published: 2020

Alkaline electrolyzed water (AEW) and walking are strongly recommended for ameliorating oxidative stress and inflammation. Nevertheless, there is a lack of information on the combination of both on alleviating inflammation, oxidative stress, and improving the quality of life (QoL). We investigated the synergistic effects of drinking AEW and walking on advanced glycation end products (AGEs), ...
WHOLE BODY - HYDROGEN BIOLOGY

Antioxidant effects of continuous intake of electrolyzed hydrogen water in healthy adults

Year Published: 2022

Chronic oxidative stress induces deterioration of health and a risk for the onset of various diseases. Previous clinical studies revealed that electrolyzed hydrogen water (EHW) is effective to reduce oxidative stress during hemodialysis in patients with chronic dialysis. In the present observational study, we investigated the antioxidant effects of a daily continuous intake of EHW in healthy ...
BRAIN - GUT MICROBIOME

Effect of molecular hydrogen treatment on Sepsis-Associated encephalopathy in mice based on gut ...

Year Published: 2022

Introduction: In our experiments, male wild-type mice were randomly divided into four groups: the sham, SAE, SAE + 2% hydrogen gas inhalation (H2 ), and SAE + hydrogen-rich water (HW) groups. The feces of the mice were collected for 16 S rDNA analysis 24 h after the models were established, and the serum and brain tissue of the mice were collected for nontargeted metabolomics analysis. Aim: ...
BRAIN - SEPSIS

Effects of hydrogen-rich saline in neuroinflammation and mitochondrial dysfunction in rat model of ...

Year Published: 2022

Background: Sepsis-associated encephalopathy (SAE) is one of the most common types of sepsis-related organ dysfunction without overt central nervous system (CNS) infection. It is associated with higher mortality, low quality of life, and long-term neurological sequelae in suspected patients. At present there is no specific treatment for SAE rather than supportive therapy and judicious use of ...
INTESTINE - EXCERCISE

Effects of Intestinal Bacterial Hydrogen Gas Production on Muscle Recovery following Intense ...

Year Published: 2022

This study aimed to examine the effects of hydrogen gas (H2) produced by intestinal microbiota on participant conditioning to prevent intense exercise-induced damage. In this double-blind, randomized, crossover study, participants ingested H2-producing milk that induced intestinal bacterial H2 production or a placebo on the trial day, 4 h before performing an intense exercise at 75% maximal oxygen ...
LUNG - CHRONIC OBSTRUCTIVE PULMONARY DISEASE

The effects of hydrogen treatment in a cigarette smoke solution-induced chronic obstructive ...

Year Published: 2022

Background: Molecular hydrogen, with its antioxidant and anti-inflammatory properties, may be suitable for the prevention and treatment of chronic obstructive pulmonary disease (COPD). This study aims to investigate the therapeutic efficacy of hydrogen-oxygen (H2/O2) treatment in cigarette smoke solution (CSS)-induced COPD-like injury in a female BALB/c mouse model. Methods: Thirty mice were ...
INTESTINE - EXCERCISE

Hydrogen improves exercise endurance in rats by promoting mitochondrial biogenesis

Year Published: 2022

Background: Previous studies have shown that hydrogen water has antioxidant and anti-inflammatory effects on exercise-induced fatigue; however, its molecular mechanism remains unclar. Methods: Adult male Sprague-Dawley rats were randomly divided into a pure water drinking group (NC) and a hydrogen water drinking group (HW) (n = 7), and 2-week treadmill training was used to establish a sports ...
EAR - HEARING LOSS

A double-blinded, randomized controlled clinical trial of hydrogen inhalation therapy for idiopathic ...

Year Published: 2022

Background: Hydrogen (H2) has been reported to be effective in reducing hearing loss due to several causes in animal studies. However, no study has examined the effectiveness of H2 in treating hearing loss in humans. Thus, we investigated whether H2 is effective for the treatment of idiopathic sudden sensorineural hearing loss (ISSNHL). Materials and methods: We conducted a double-blind randomized ...
INTESTINE - GUT MICROBIOME

Effects of molecular hydrogen intervention on the gut microbiome in methamphetamine abusers with ...

Year Published: 2022

Methamphetamine (METH) is a potent and highly addictive psychostimulant and one of the most widely used illicit drugs, the abuse of which has become a severe public health problem worldwide. A growing amount of evidence has indicated potential connections between gut microbiota and mental disorders induced by METH and associations with neural and metabolic pathways. The present study aimed to ...
INTESTINE - ENTEROPATHY

Ameliorating Role of Hydrogen-Rich Water Against NSAID-Induced Enteropathy via Reduction of ROS and ...

Year Published: 2022

Background: Nonsteroidal anti-inflammatory drug (NSAID)-induced enteropathy, the mechanism of which is involved in oxidative stress, can be lethal due to hemorrhage. Thus, we aimed to investigate the effect of hydrogen-rich water (HRW), in terms of oxidative stress, on intestinal mucosal damage as well as changes in the gut microbiome and the short-chain fatty acids (SCFAs) content in feces. ...
WHOLE BODY - HYDROGEN BIOLOGY

Silicon nanoparticles for oral administration of molecular hydrogen

Year Published: 2022

Medical use of hydrogen gas (H2) has been given increasing attention over the past 15 years with numerous clinical trials for a variety of indications. The biological activity of H2 includes antioxidant properties and thereby the ability to neutralize damaging reactive oxygen species (ROS). Administration of hydrogen as a medical gas is limited by the poor water solubility and by the flammability ...
INTESTINE - SEPSIS

Hydrogen-Rich Water Mitigates LPS-Induced Chronic Intestinal Inflammatory Response in Rats via Nrf-2 ...

Year Published: 2022

Long-term exposure to low-dose lipopolysaccharide can impair intestinal barriers, causing intestinal inflammation and leading to systemic inflammation. Hydrogen-rich water possesses antioxidant and anti-inflammatory functions and exerts inhibitory effects on various inflammatory diseases. In this study, we investigated whether oral hydrogen-rich water could prevent lipopolysaccharide-induced ...
BONE - RHEUMATOID ARTHRITIS

NIR-photocatalytic regulation of arthritic synovial microenvironment

Year Published: 2022

Synovial microenvironment (SME) plays a vital role in the formation of synovial pannus and the induction of cartilage destruction in arthritis. In this work, a concept of the photocatalytic regulation of SME is proposed for arthritis treatment, and monodispersive hydrogen-doped titanium dioxide nanorods with a rutile single-crystal structure are developed by a full-solution method to achieve near ...
PREGNANCY - PREECLAMPSIA

Hydrogen suppresses oxidative stress by inhibiting the p38 MAPK signaling pathway in preeclampsia

Year Published: 2022

Background: Hypertensive disorders complicating pregnancy (HDCP) are one of the most serious medical disorders during pregnancy. Objectives: To investigate the effects of hydrogen on the mitogen-activated protein kinase (MAPK) signaling pathway in preeclampsia (PE). Material and methods: The N(omega)-nitro-L-arginine methyl ester (L-NAME)-induced PE model with Sprague Dawley (SD) rats was ...
HEART - AGING

The effect of a low dose hydrogen-oxygen mixture inhalation in midlife/older adults with ...

Year Published: 2022

Objective: To explore the effect of a low-dose hydrogen-oxygen (H2-O2) mixture inhalation in midlife/older adults with hypertension. Methods: This randomized, placebo-controlled trial included 60 participants with hypertension aged 50-70 years who were randomly divided into Air group (inhaled placebo air) or H2-O2 group [inhaled H2-O2 mixture (66% H2/33% O2)]. Participants in both groups were ...
WHOLE BODY - SARS/COVID

Hydrogen effect on the mechanisms of mucosal immunity in patients with COVID-19

Year Published: 2022

Aim: To study the inhalation of an active form of hydrogen effect to mucosal and system immunity in a rehabilitation program for health workers. Materials and methods: The study involved patients that survived COVID-19 after therapy with inhaled hydrogen for 90 minutes (n=30), and a control group of patients treated according to standard protocol for managing patients that survived COVID-19 during ...
INTESTINE - INFLAMMATORY BOWEL DISEASE

Electrolyzed Hydrogen Water Alleviates Abdominal Pain through Suppression of Colonic Tissue ...

Year Published: 2022

Inflammatory bowel disease (IBD) is characterized by chronic inflammation of the digestive tract and is typically accompanied by characteristic symptoms, such as abdominal pain, diarrhea, and bloody stool, severely deteriorating the quality of the patient's life. Electrolyzed hydrogen water (EHW) has been shown to alleviate inflammation in several diseases, such as renal disease and ...
BRAIN - CARDIAC ARREST

Influence of oxygen concentration on the neuroprotective effect of hydrogen inhalation in a rat ...

Year Published: 2022

Background: Post-cardiac arrest (CA) brain injury is the main cause of death in patients resuscitated from CA. Previous studies demonstrated that hydrogen inhalation mitigates post-CA brain injury. However, factors affecting the efficacy of hydrogen remain unknown. In the present study, we investigated the influence of oxygen concentration and targeted temperature on neuroprotective effect in a CA ...