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Studies Found: 1335

WHOLE BODY - EXCERCISE

Hydrogen Rich Water Improved Ventilatory, Perceptual and Lactate Responses to Exercise

Year Published: 2019

The potential anti-fatigue and performance benefits of hydrogen rich water (HRW) have resulted in increased research interest over the past 5 years. The aim of this study was to assess physiological and perceptual responses to an incremental exercise protocol after administration of 600 ml HRW within 30 min before exercise. This randomized, double blinded placebo-controlled cross over study ...
INTESTINE - CANCER

Hydrogen gas restores exhausted CD8+ T cells in patients with advanced colorectal cancer to improve ...

Year Published: 2019

Exhausted cluster of differentiation (CD)8+ T cells lose immunological activity due to mitochondrial dysfunction caused by peroxisome proliferator‑activated receptor γ coactivator 1α (PGC‑1α) inactivation, resulting in a poor prognosis in patients with cancer. As hydrogen gas was recently reported to activate PGC‑1α, the present study investigated whether it restores exhausted CD8+ T ...
SKIN - COSMETIC SKIN ISSUES

Effects of hydrogen-rich water bath on visceral fat and skin blotch, with boiling-resistant hydrogen ...

Year Published: 2019

Hydrogen-dissolved water has been shown to improve diverse oxidation stress-related diseases, which drove us to examine effects of hydrogen-rich water on oxidation stress-related skin troubles and lipid-metabolism markers. The purpose of this study is whether the dissolved hydrogen in hydrogen-rich water was kept even after boiling, and whether hydrogen-bath utilization improves cosmetic effects ...
BRAIN - DEMENTIA

Effect of Hydrogen Water Drinking on Dementia Patient through Mechanism of Oxidative Stress and ...

Year Published: 2019

Hydrogen water (HW) which is produced by electrolysis of water has characteristics of extremely low oxidation-reduction potential (ORP) value and high dissolved hydrogen (DH). It has been proved to have various beneficial effects including antioxidant and anti-inflammatory effects; however, HW effect on dementia that is associated with cognitive impairment and memory loss, is poorly documented. In ...
INTESTINE - PARKINSON'S DISEASE

Positive effect of an electrolyzed reduced water on gut permeability, fecal microbiota and liver in ...

Year Published: 2019

There is growing awareness within the scientific community of the strong connection between the inflammation in the intestine and the pathogenesis of Parkinson's disease (PD). In previous studies we developed a PD animal model exposing pup rats to permethrin (PERM) pesticide. Here, we intended to explore whether in our animal model there were changes in gut permeability, fecal microbiota and ...
BRAIN - BRAIN INJURY

Hydrogen Inhalation Attenuates Oxidative Stress Related Endothelial Cells Injury After Subarachnoid ...

Year Published: 2020

Background: Subarachnoid hemorrhage (SAH) is a devastating cerebrovascular disease with poor clinical outcome. Nucleotide binding and oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome serves a key role in inflammatory response, which may lead to endothelial cell injury and blood-brain barrier (BBB) disruption. Hydrogen (H2) is considered a neuroprotective ...
BRAIN - SEPSIS

Molecular hydrogen attenuates sepsis-induced neuroinflammation through regulation of microglia ...

Year Published: 2020

Sepsis-associated encephalopathy (SAE) is the cognitive impairment resulting from sepsis and is associated with increased morbidity and mortality. Hydrogen has emerged as a promising therapeutic agent to alleviate SAE. The mechanism, however, remains unclear. This research aimed to determine whether hydrogen alleviates SAE by regulating microglia polarization and whether it is mediated by the ...
BRAIN - ENVIRONMENTAL POLLUTION

Hydrogen rich water ameliorate Trimethyltin induced spatial learning and memory impairment by ...

Year Published: 2020

Background: As an important member of organic tin compounds, Trimethyltin (TMT) exists widely in industrial and agricultural productions. TMT can induce significant neurodegeneration in the limbic system, particular in hippocampus. However, the molecular mechanisms in TMT-induced learning and memory impairment are not fully clear. Thus, this research was to explore the role of Synaptophysin (SYP) ...
LIVER - SURGERY/TRANSPLANTATION

Protective effects of hydrogen on oxidative stress and liver function during CO2 pneumoperitoneum in ...

Year Published: 2020

The purpose of this study was to investigate the protective effects of hydrogen reducing ischemia-reperfusion injury during CO2 pneumoperitoneum on oxidative stress and liver function. Eighteen healthy Beagle dogs were divided into three groups. Dogs in the control group were subjected only to anesthesia for 90 min. The pneumoperitoneum group was subjected to the pressure of CO2 pneumoperitoneum ...
HEART - SEPSIS

Protective Effects of Hydrogen on Myocardial Mitochondrial Functions in Septic Mice

Year Published: 2020

Enhancement of mitochondrial physiological function prevents sepsis-induced dysfunction. The present study aimed to elucidate the mechanism by which hydrogen (H2) affects mitochondrial function in a wild-type (WT) and homozygous nuclear factor erythroid 2-related factor 2 (Nrf2) knockout (KO, Nrf2−/−) murine model of sepsis. In myocardial tissues with severe sepsis, H2 gas treatment reduced ...
BRAIN - TRAUMATIC BRAIN INJURY

Hydrogen inhalation inhibits microglia activation and neuroinflammation in a rat model of traumatic ...

Year Published: 2020

Traumatic brain injury (TBI) is a major cause of mortality and disability worldwide. To date, therapies to treat any forms of TBI are still limited. Recent studies have demonstrated the potential neuroprotective effects of molecular hydrogen on TBI. Although it has been demonstrated that hydrogen inhalation (HI) for about 5 hrs immediately after TBI has a beneficial effect on brain injury, the ...
BRAIN - SEPSIS

Hydrogen gas alleviates blood-brain barrier impairment and cognitive dysfunction of septic mice in ...

Year Published: 2020

Sepsis-associated encephalopathy (SAE) is a cognitive impairment caused by sepsis and is related to increased morbidity and mortality. Damage to the blood-brain barrier (BBB) has been proved to be one of the important causes of SAE. Molecular hydrogen (H2) is a promising method for the treatment of SAE, yet the underlying mechanism is not clear. This study was designed to demonstrate whether H2 ...
BRAIN - SLEEP DEPRIVATION

Hydrogen vs. Caffeine for Improved Alertness in Sleep-Deprived Humans

Year Published: 2020

Molecular hydrogen (H2) has been suggested as an agent capable of exerting neuromodulating effects; yet, its potential to affect brain circuits linked to alertness remains poorly examined. In this randomized controlled cross-over pilot trial, we compared acute effects of single-dose hydrogen-rich water (HRW) and caffeine on estimates by the Visual Analog Scale (VAS) for alertness and on Attention ...
UTERUS - CANCER

Hydrogen inhibits endometrial cancer growth via a ROS/NLRP3/caspase-1/GSDMD-mediated pyroptotic ...

Year Published: 2020

Background: Pyroptosis belongs to a novel inflammatory programmed cell death pathway, with the possible prognosis of endometrial cancer related to the terminal protein GSDMD. Hydrogen exerts a biphasic effect on cancer by promoting tumor cell death and protecting normal cells, which might initiate GSDMD pathway-mediated pyroptosis. Methods: We performed immunohistochemical staining and western ...
INTESTINE - SEPSIS

Hydrogen plays a protective role in intestinal injury of mice with severe sepsis by regulating the ...

Year Published: 2020

Objective: To investigate the protective effect of the hydrogen (H2) inhalation on intestinal injury in severe sepsis mice and its relationship with nuclear factor E2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1)/high mobility group protein B1 (HMGB1) pathway. Methods: The 280 male wild-type (WT) and Nrf2 knockout (Nrf2-KO) ICR mice (6-8 weeks old, 20-25 g weight) were assigned into 8 groups ...
INTESTINE - SURGERY/TRANSPLANTATION

Luminal preloading with hydrogen-rich saline ameliorates ischemia-reperfusion injury following ...

Year Published: 2020

Prolonged intestinal cold storage causes considerable mucosal breakdown, which could bolster bacterial translocation and cause life-threatening infection for the transplant recipient. The intestine has an intraluminal compartment, which could be a target for intervention, but has not yet been fully investigated. Hydrogen gas exerts organ protection and has used been recently in several clinical ...
INTESTINE - BLOOD COMPOSITION

Amelioration of Coagulation Disorders and Inflammation by Hydrogen-Rich Solution Reduces Intestinal ...

Year Published: 2020

Intestinal ischemia/reperfusion (I/R) injury often causes inflammatory responses and coagulation disorders, which is further promoting the deterioration of the disease. Hydrogen has anti-inflammatory, antioxidative, and antiapoptotic properties against various diseases. However, the effect of hydrogen on coagulation dysfunction after intestinal I/R and the underlying mechanism remains unclear. The ...
WHOLE BODY - BLOOD COMPOSITION

Effects of long-term hydrogen intervention on the physiological function of rats

Year Published: 2020

The potential therapeutic effects of molecular hydrogen (H2) have now been confirmed in various human and animal-disease models. However, the effects of H2 on the physiological function in a normal state have been largely neglected. Hydrogen-rich water (HRW) intake and hydrogen inhalation (HI) are the most common used methods for hydrogen administration, the difference in the effects between HRW ...
LIVER - ENVIRONMENTAL POLLUTION

Protective effects of molecular hydrogen on hepatotoxicity induced by sub-chronic exposure to ...

Year Published: 2020

Introduction: Chlorpyrifos (CPF) is a organophosphate insecticide widely used in agriculture with attendant adverse health outcomes. Chronic exposure to CPF induces oxidative stress and elicits harmful effects, including hepatic dysfunction. Molecular hydrogen has been identified as a novel antioxidant which could selectively scavenge hydroxyl radicals. Objective: The aim of this study was to ...
LIVER - NON-ALCOHOLIC STEATOHEPATITIS

Abstract: Oral Hydrogen water – reduce hepatic inflammatory cells in mouse

Year Published: 2019

No abstract available
BRAIN - SEPSIS

Hydrogen Gas Alleviates Sepsis-Induced Brain Injury by Improving Mitochondrial Biogenesis Through ...

Year Published: 2020

Sepsis-associated encephalopathy (SAE) affects approximately one-third of septic patients, and there is a lack of effective therapeutics for SAE. Hydrogen gas is a new medical gas that exerts anti-inflammation, antioxidation, and anti-apoptotic effects and can effectively protect septic mice. Mitochondrial dysfunction, which can be improved by mitochondrial biogenesis, is a type of molecular ...
BRAIN - SEPSIS

Hydrogen attenuates sepsis-associated encephalopathy by NRF2 mediated NLRP3 pathway inactivation

Year Published: 2020

Objective Sepsis-associated encephalopathy (SAE) is a major cause of mortality worldwide. Oxidative stress, inflammatory response and apoptosis participate in the pathogenesis of SAE. Nuclear factor erythroid 2-related factor 2 (Nrf2) and nucleotide-binding oligomerization domain-like receptor containing pyrin domain 3 (NLRP3) pathway is involved in oxidative stress and inflammatory response. We ...
BRAIN - ADDICTION

Molecular hydrogen attenuates methamphetamine-induced behavioral sensitization and activation of ...

Year Published: 2020

Methamphetamine (METH) is one of the most prevalently used illegal psychostimulants in many countries. Continuous exposure to METH leads to behavioral sensitization in animals, which can be used as a behavioral model with many mechanisms in common with relapse in humans. Molecular hydrogen has recently gained attention for its potential as a novel healthcare product with preventive and therapeutic ...
KIDNEY - ACUTE KIDNEY INJURY

Saturated hydrogen alleviates CCl 4 -induced acute kidney injury via JAK2/STAT3/p65 signaling

Year Published: 2020

Objectives: This study assessed the protective effects of saturated hydrogen against CCl4-induced acute kidney injury (AKI) in mice, and investigated signaling pathways activated by exposure to saturated hydrogen. Methods: A mouse model of CCl4-induced AKI was established; some mice were treated with saturated hydrogen. Levels of cystatin C and kidney injury molecule 1 were determined using ...
BRAIN - TRAUMATIC BRAIN INJURY

Hydrogen improves cell viability partly through inhibition of autophagy and activation of ...

Year Published: 2020

Objective：Traumatic brain injury (TBI) is one of the most serious public health problems in the world. Hydrogen (H2), a flammable, colorless, and odorless gas, has been observed to have preventive and therapeutic effects on brain trauma and other neurological disorders, but its exact mechanism has not been fully clarified. Methods: To further study the mechanism underlying the role of hydrogen ...