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Studies Found: 1335

WHOLE BODY - CANCER

Antioxidant Effect of Hydrogen Nanobubble Contributes to Suppression of Tumor Cell Growth

Year Published: 2019

The antitumor effect of hydrogen nanobubble was evaluated in vitro and in vivo. Cancer cell growth was inhibited in the hydrogen nanobubble-containing medium compared to the non-containing medium (in vitro). Tumor growth was significantly suppressed in the middle stage of transplantation (in vivo). We reported that hydrogen nanobubbles is a ROS scavenger, therefore apoptosis due to ROS reduction ...
WHOLE BODY - EXCERCISE

Acute Supplementation with Molecular Hydrogen Benefits Submaximal Exercise Indices. Randomized, ...

Year Published: 2019

Background: Clinical studies have reported hydrogen-rich water (HRW) to have therapeutic and ergogenic effects. The aim of this study was to determine the effect of acute supplementation with HRW on exercise performance as measured by VO2, respiratory exchange ratio (RER), heart rate (HR), and respiratory rate (RR). Methods: Baseline levels of all exercise indices were determined in nineteen (4 ...
WHOLE BODY - CANCER

Acid-responsive H2-releasing Fe nanoparticles for safe and effective cancer therapy

Year Published: 2019

Hydrogen therapy is an emerging and promising strategy for treatment of inflammation-related diseases owing to excellent bio-safety of hydrogen molecule (H2), but is facing a challenge that the H2 concentration at the local disease site is hardly accumulated because of its high diffusibility and low solubility, limiting the efficacy of hydrogen therapy. Herein, we propose a nanomedicine strategy ...
HEART - CANCER

Regulation of microRNAs by molecular hydrogen contributes to the prevention of radiation-induced ...

Year Published: 2019

microRNAs (miRNAs) constitute a large class of post-transcriptional regulators of gene expression. It has been estimated that miRNAs regulate up to 30% of the protein-coding genes in humans. They are implicated in many physiological and pathological processes, including those involved in radiation-induced heart damage. Biomedical studies indicate that molecular hydrogen has potential as a ...
WHOLE BODY - AGING

Supplementation with hydrogen-producing composition confers beneficial effects on physiology and ...

Year Published: 2019

Recently, molecular hydrogen (H 2 )has become known as a new class of antioxidants and redox-modulating interventions. Effects of H 2 have been documented for many acute and chronic pathological conditions. The present study was aimed at determining the effect of hydrogen on the physiology and longevity of Drosophila. The flies were given a patented food supplement consisting of a mixture of inert ...
KIDNEY - SURGERY/TRANSPLANTATION

Organ preservation solution containing dissolved hydrogen gas from a hydrogen-absorbing alloy ...

Year Published: 2019

Various methods have been devised to dissolve hydrogen gas in organ preservation solutions, including use of a hydrogen gas cylinder, electrolysis, or a hydrogen-generating agent. However, these methods require considerable time and effort for preparation. We investigated a practical technique for rapidly dissolving hydrogen gas in organ preservation solutions by using a canister containing ...
LIVER - FATTY LIVER DISEASE (NONALCOHOLIC)

Hydrogen-rich water reduces liver fat accumulation and improves liver enzyme profiles in patients ...

Year Published: 2019

Background and aims: While non-alcoholic fatty liver disease (NAFLD) is rapidly becoming the most common liver disease worldwide, its treatment remains elusive. Since metabolic impairment plays a major role in NAFLD pathogenesis, any pharmaceuticals, such as molecular hydrogen (H2), that advance lipid and glucose metabolism could be appropriate to tackle this complex condition. The aim of this ...
BRAIN - DEMENTIA

FoxO1-mediated autophagy plays an important role in the neuroprotective effects of hydrogen in a rat ...

Year Published: 2019

Vascular dementia (VD) is a heterogeneous group of brain disorders in which cognitive impairment is attributed to cerebrovascular pathologies. Autophagy, a self-cannibalization mechanism, has been demonstrated to be involved in VD progression. Molecular hydrogen is known for its powerful anti-oxidative, anti-apoptotic, and anti-inflammatory activities, and it is also involved in autophagy. ...
LIVER - EXCERCISE

Hydrogen water intake may suppress liver glycogen utilization without affecting redox biomarkers ...

Year Published: 2019

BACKGROUND: Studies have revealed that molecular hydrogen (H2) exhibits therapeutic effects against various diseases through biological activities such as antioxidation. However, little is known about the effects of H2 on redox biomarkers and related indicators during exercise. Therefore, we examined whether 2 weeks of H2 water intake could affect the redox biomarkers, energy metabolism, and ...
BRAIN - SEIZURE

Hydrogen Alleviates Necroptosis and Cognitive Deficits in Lithium–Pilocarpine Model of Status ...

Year Published: 2019

Status epilepticus without prompt seizure control always leads to neuronal death and long-term cognitive deficits, but effective intervention is still absent. Here, we found that hydrogen could alleviate the hippocampus-dependent spatial learning and memory deficit in lithium–pilocarpine model of status epilepticus in rats, as evidenced by the results in Morris water maze test. Hydrogen ...
WHOLE BODY - EXCERCISE

Short-term H2 inhalation improves running performance and torso strength in healthy adults

Year Published: 2019

In this randomized, double-blind, placebo-controlled, crossover pilot trial, we evaluated the effects of 7-day H2 inhalation on exercise performance outcomes and serum hormonal and inflammation profiles in a cohort of young men and women. All participants (age 22.9 ± 1.5 years; body mass index 23.4 ± 2.5 kg m-2; 10 women and 10 men) were allocated to receive either gaseous hydrogen (4%) or ...
INTESTINE - FOOD POISONING

Morphological and molecular response of small intestine to lactulose and hydrogen-rich water in ...

Year Published: 2019

Background Following the intake of Fusarium mycotoxin-contaminated feed, small intestines may be exposed to high levels of toxic substances that can potentially damage intestinal functions in livestock. It is well known that Fusarium mycotoxins will lead a breakdown of the normally impeccable epithelial barrier, resulting in the development of a “leaky” gut. H2 administration with different ...
INTESTINE - FOOD POISONING

Protective Role of Hydrogen Gas on Oxidative Damage and Apoptosis in Intestinal Porcine Epithelial ...

Year Published: 2019

To explore the protective role of hydrogen gas (H2) on oxidative damage and apoptosis in intestinal porcine epithelial cells (IPEC-J2) induced by deoxynivalenol (DON), cells were assigned to four treatment groups, including control, 5 μM DON, H2-saturated medium, and 5 μM DON + H2-saturated medium treatments. After 12 h of different treatments, the cell viability, biomarkers of cell redox ...
WHOLE BODY - ROS-SCAVENGING

Hydrogen produced in rat colon improves in vivo redox balance due to induced regeneration of ...

Year Published: 2019

We investigated whether non-digestible saccharide fermentation-derived hydrogen molecules (H 2 ) in rat colon could improve the in vivo reduction–oxidation balance via regeneration of α-tocopherol, by assessing their effect on hydroxyl radicals, the α-tocopherol concentration and the reduction–oxidation balance. In experiment 1, a Fenton reaction with phenylalanine (0 or 1.37 mmol/L of H 2 ) ...
WHOLE BODY - MITOCHONDRIAL FUNCTION

Molecular hydrogen suppresses free-radical-induced cell death by mitigating fatty acid peroxidation ...

Year Published: 2019

Molecular hydrogen (H2) was believed to be an inert and nonfunctional molecule in mammalian cells; however, we overturned the concept by reporting the therapeutic effects of H2 against oxidative stress. Subsequently, extensive studies revealed multiple functions of H2 by exhibiting the efficacies of H2 in various animal models and clinical studies. Here, we investigated the effect of H2 on ...
BRAIN - TRAUMATIC BRAIN INJURY

Case Report: Buccal administration of hydrogen-producing blend after a mild traumatic brain injury ...

Year Published: 2019

Background: Sport-related mild traumatic brain injury (TBI) is a serious trauma that could impair brain function of an injured athlete. Treatment solutions for mild TBI typically concentrate on complete rest, while non-traditional therapeutic options remain largely ineffective. Molecular hydrogen (H 2 ) is an innovative neuroprotective agent that can easily reach the brain, yet no data are ...
LUNG - ASTHMA

Hydrogen gas inhalation enhances alveolar macrophage phagocytosis in an ovalbumin-induced asthma ...

Year Published: 2019

Background: Maintaining an airway clear of bacteria, foreign particles and apoptotic cells by alveolar macrophages is very essential for lung homeostasis. In asthma, the phagocytic capacity of alveolar macrophages is significantly reduced, which is thought to be associated with increased oxidative stress. Hydrogen (H2) has been shown to exert potent antioxidant and anti-inflammatory effects, yet ...
EYE - SURGERY/TRANSPLANTATION

Effects of Hydrogen in Prevention of Corneal Endothelial Damage During Phacoemulsification: A ...

Year Published: 2019

Purpose: Hydrogen (H2) has been reported to scavenge free radicals, particularly the hydroxyl radical (·OH). Ultrasound oscillation in an aqueous solution produces ·OH. Our recent study demonstrated that H2 dissolved in an irrigation solution prevented corneal endothelial damage during phacoemulsification in an animal model. We examined the effects of H2 during clinical phacoemulsification. ...
BRAIN - STROKE

Hydrogen inhibits microglial activation and regulates microglial phenotype in a mouse middle ...

Year Published: 2019

Microglia participate in bi-directional control of brain repair after stroke. Previous studies have demonstrated that hydrogen protects brain after ischemia/reperfusion (I/R) by inhibiting inflammation, but the specific mechanism of anti-inflammatory effect of hydrogen is poorly understood. The goal of our study is to investigate whether inhalation of high concentration hydrogen (HCH) is able to ...
BRAIN - CARDIOPULMONARY RESUSCITATION (CPR)

Inhalation of high-concentration hydrogen gas attenuates cognitive deficits in a rat model of ...

Year Published: 2019

Cognitive deficits are a devastating neurological outcome seen in survivors of cardiac arrest. We previously reported water electrolysis derived 67% hydrogen gas inhalation has some beneficial effects on short-term outcomes in a rat model of global brain hypoxia-ischemia induced by asphyxia cardiac arrest. In the present study, we further investigated its protective effects in long-term spatial ...
LIVER - FOOD POISONING

Anti-injury effect of hydrogen-enriched water in a rat model of liver injury induced by aflatoxin B1

Year Published: 2019

The purpose of this study was to investigate the anti-injury effect and protective mechanism of hydrogen-enriched water in a rat model of acute liver injury induced by aflatoxin B1 (AFB1). Healthy male Sprague-Dawley (SD) rats were randomly divided into control group, model group (AFB1 group) and hydrogen-enriched water treatment group (AFB1+H2 group). The rat model of acute liver injury induced ...
BRAIN - PARKINSON'S DISEASE

Inhalation of hydrogen gas elevates urinary 8-hydroxy-2′-deoxyguanine in Parkinson’s ...

Year Published: 2019

Hyposmia is one of the earliest and the most common symptoms in Parkinson's disease (PD). The benefits of hydrogen water on motor deficits have been reported in animal PD models and PD patients, but the effects of hydrogen gas on PD patients have not been studied. We evaluated the effect of inhalation of hydrogen gas on olfactory function, non-motor symptoms, activities of daily living, and ...
BRAIN - BRAIN INJURY

Hydrogen ventilation combined with mild hypothermia improves short-term neurological outcomes in a ...

Year Published: 2019

Despite its poor outcomes, therapeutic hypothermia (TH) is the current standard treatment for neonatal hypoxic-ischaemic encephalopathy (HIE). In this study, due to its antioxidant, anti-inflammatory, and antiapoptotic properties, the effectiveness of molecular hydrogen (H2) combined with TH was evaluated by means of neurological and histological assessments. Piglets were divided into three ...
SKIN - SURGERY/TRANSPLANTATION

Preconditioning with one-time hydrogen gas does not attenuate skin flap ischemia-reperfusion injury ...

Year Published: 2019

Background: Hydrogen gas exists in the atmosphere and was previously considered an inert gas. It has been reported to have protective effects on tissue ischemia-reperfusion (IR) injuries in animal models. The protective mechanism of hydrogen molecules is based on selectively reducing highly strong oxidants in cells, thereby reducing inflammation and decreasing the contents of MDA, FOXO3a, and ...
BONE MARROW - CANCER

Hydrogen Gas Inhalation Alleviates Radiation-Induced Bone Marrow Damage in Cancer Patients

Year Published: 2019

Abstract: Background: Radiotherapy for cancer patients is one of the useful methods; however, it not only impairs the targeted tumor tissues but also damage the normal surrounding tissues. Intensity modulated radiation therapy (IMRT) for cancer patients has been recently performed to alleviate the adverse effects, but reducing bone marrow damage is limited in the patients with multiple tumor ...