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Studies Found: 1335

BRAIN - SURGERY/TRANSPLANTATION

Hydrogen Gas Treatment Improves Postoperative Delirium and Cognitive Dysfunction in Elderly ...

Year Published: 2022

Purpose: Postoperative delirium is a state of acute brain dysfunction characterized by fluctuating mental status that affects millions of patients each year. We used prophylactic inhalation of hydrogen gas in elderly patients undergoing elective surgery to compare their occurrence of postoperative delirium with that of controls. Methods: A total of 184 patients aged ≥ 65 years were enrolled and ...
SKIN - WOUND HEALING

Molecular hydrogen promotes wound healing by inducing early epidermal stem cell proliferation and ...

Year Published: 2023

Background: Despite progress in developing wound care strategies, there is currently no treatment that promotes the self-tissue repair capabilities. H2 has been shown to effectively protect cells and tissues from oxidative and inflammatory damage. While comprehensive effects and how H2 functions in wound healing remains unknown, especially for the link between H2 and extracellular matrix (ECM) ...
LIVER - SURGERY/TRANSPLANTATION

Hypothermic Machine Perfusion with Hydrogen Gas Reduces Focal Injury in Rat Livers but Fails to ...

Year Published: 2023

Background: We have previously reported the efficacy of post-reperfusion H2 gas treatment in cold storage (CS) and subsequent reperfusion of the rat liver. The present study aimed to evaluate the effect of H2 gas treatment during hypothermic machine perfusion (HMP) in rat livers retrieved from donation after circulatory death (DCD) and elucidate the mechanism of action of H2 gas. Methods: Liver ...
BRAIN - SEPSIS

Hydrogen regulates mitochondrial quality to protect glial cells and alleviates sepsis-associated ...

Year Published: 2023

Background: Sepsis-associated encephalopathy (SAE) is a complication of the central nervous system in patients with sepsis. Currently, no effective treatment for sepsis is available. Hydrogen plays a protective role in different diseases; however, the detailed mechanism of hydrogen-treated disease remains unclear. The purpose of this study was to investigate the effect of hydrogen on SAE in vitro ...
BRAIN - CARDIAC ARREST

Efficacy of inhaled hydrogen on neurological outcome following brain ischaemia during post-cardiac ...

Year Published: 2023

Background: Inhaled molecular hydrogen gas (H2) has been shown to improve outcomes in animal models of cardiac arrest (CA). H2 inhalation is safe and feasible in patients after CA. We investigated whether inhaled H2 would improve outcomes after out-of-hospital CA (OHCA). Methods: HYBRID II is a prospective, multicentre, randomised, double-blind, placebo-controlled trial performed at 15 hospitals ...
LIVER - LIVER DISEASE

Hydrogen inhalation ameliorates hepatic inflammation and modulates gut microbiota in rats with ...

Year Published: 2023

Nonalcoholic fatty liver disease (NAFLD) is a multisystem metabolic disease associated with gut microflora dysbiosis and inflammation. Hydrogen (H2) is a novel and effective antiinflammatory agent. The present study was aimed to clarify the effects of 4% H2 inhalation on NAFLD and its mechanism of action. Sprague-Dawley rats were fed a high-fat diet for 10 weeks to induce NAFLD. Rats in treatment ...
SKIN - WOUND HEALING

Effect of Hydrogen on AM Pyroptosis Induced by Severe Burns in Rats

Year Published: 2023

Background: Hydrogen has anti-inflammatory and antioxidant effects and is beneficial to multiple organs. However, its effect on alveolar macrophage (AM) pyroptosis induced by burns is still unclear. The purpose of this research was to study the possible positive effects of hydrogen on burn-induced lung injury and the effects of hydrogen on AM pyroptosis during acute lung injury (ALI) induced by ...
BRAIN - ALZHEIMER'S DISEASE

Therapeutic Inhalation of Hydrogen Gas for Alzheimer’s Disease Patients and Subsequent ...

Year Published: 2023

(1) Background: Alzheimer's disease (AD) is a progressive and fatal neurodegenerative disorder. Hydrogen gas (H2) is a therapeutic medical gas with multiple functions such as anti-oxidant, anti-inflammation, anti-cell death, and the stimulation of energy metabolism. To develop a disease-modifying treatment for AD through multifactorial mechanisms, an open label pilot study on H2 treatment was ...
HEART - CANCER

Hydrogen inhalation enhances autophagy via the AMPK/mTOR pathway, thereby attenuating ...

Year Published: 2023

Aims: Doxorubicin is a drug widely used in clinical cancer treatment, but severe cardiotoxicity limits its clinical application. Autophagy disorder is an important factor in the mechanism of doxorubicin-induced cardiac injury. As the smallest molecule in nature, hydrogen has various biological effects such as anti-oxidation, anti-apoptosis and regulation of autophagy. Hydrogen therapy is currently ...
SKIN - WOUND HEALING

Mast Cells in Regeneration of the Skin in Burn Wound with Special Emphasis on Molecular Hydrogen ...

Year Published: 2023

The mechanisms of regeneration for the fibrous component of the connective tissue of the dermis are still insufficiently studied. The aim of this study was to evaluate the effectiveness of the use of molecular hydrogen on the local therapy of a II degree burn wound with the intensification of collagen fibrillogenesis in the skin. We analyzed the involvement of mast cells (MCs) in the regeneration ...
HEART - HIGH BLOOD PRESSURE

Protective Effects of Different Kinds of Filtered Water on Hypertensive Mouse by Suppressing ...

Year Published: 2018

Oxidative stress and inflammation play an important role in hypertensive animals and patients. Hydrogen plays a role of antioxidation and anti-inflammation. Calcium and magnesium play an important role in reducing hypertension and antioxidant. Filtered water contains abundant hydrogen and a large number of other essential elements of the human body. We investigated the protective effects of ...
WHOLE BODY - HYDROGEN BIOLOGY

Solubility of various inert gases in rat skeletal muscle

Year Published: 1975

For the determination of solubility coefficients, isolated rat abdominal muscles were equilibrated at 37 degrees C with various inert gases saturated with water vapor. After rapid transfer into a closed chamber containing room air the amount of gas extracted from the sample by diffusion was measured by gas chromatography. Corrections for unextracted gas and for gas lost during the transfer of the ...
WHOLE BODY - HYDROGEN BIOLOGY

Diffusivity of various inert gases in rat skeletal muscle

Year Published: 1975

Krogh's diffusion constant (K) was determined for various inert gases in isolated rat abdominal muscle at 37 degrees C by measuring the amount of gas diffusing per unit time and partial pressure difference through a portion of the muscle of known surface area and thickness. The following mean values for K, in 10(-9) mmol-min-1-cm-1-torr-1, were obtained: C2H2, 42.2; N2O, 20.0; CHClF2, 18.8; H2, ...
WHOLE BODY - CANCER

Rational Design of Platinum-Bismuth Sulfide Schottky Heterostructure for Sonocatalysis-Mediated ...

Year Published: 2022

Conventional sonodynamic therapy (SDT) is unavoidably limited by the tumor microenvironment although many sonosensitizers have been developed to improve them to a certain extent. Given this, we propose a concept of sonocatalytic hydrogen evolution and define it as an oxygen-independent therapeutics. To demonstrate the feasibility of the concept, narrow-bandgap semiconductor bismuth sulfide (Bi2 S3 ...
WHOLE BODY - HYDROGEN BIOLOGY

Solubility of inert gases in dog blood and skeletal muscle

Year Published: 1980

Solubility of H2, Ar, CH4 and SF6 was determined at 310 K (37 degrees C) in water, in saline (0.154 mol NaCl/l H2O), in plasma and whole blood of dogs, and in homogenates of the dog gastrocnemius muscle. The liquids were equilibrated with pure gases, and the dissolved gases were extracted and measured by gas chromatography as described previously (Meyer, M.: Pflügers Arch. 375, 161--165, 1978). ...
BRAIN - SEPSIS

Molecular hydrogen attenuates sepsis-induced cognitive dysfunction through regulation of tau ...

Year Published: 2023

Background: Sepsis-associated encephalopathy (SAE) is a cognitive dysfunction caused by sepsis. Hyperphosphorylated tau is considered to play a significant role in the progression of neurodegenerative disease and also contributes to cognitive dysfunction in septic mice. Molecular hydrogen (H2) plays an antioxidant and anti-inflammatory role, and plays a protective role in septic mice. This study ...
WHOLE BODY - EXCERCISE

Acute pre-exercise hydrogen rich water intake does not improve running performance at maximal ...

Year Published: 2022

Purpose: This study investigated the effects of acute, pre-exercise, hydrogen rich water (HRW) ingestion on running time to exhaustion at maximal aerobic speed in trained track and field runners. Methods: Twenty-four, male runners aged 17.5 ± 1.8 years, with body mass index = 21.0 ± 1.3 kg⋅m-2, and maximal oxygen uptake = 55.0 ± 4.6 ml⋅kg-1⋅min-1 (mean ± standard deviation) participated ...
EAR - HEARING LOSS

Taurine, Coenzyme Q10, and Hydrogen Water Prevents Germanium Dioxide-Induced Mitochondrial ...

Year Published: 2023

Mitochondrial dysfunction has been implicated in numerous common diseases as well as aging and plays an important role in the pathogenesis of sensorineural hearing loss (SNHL). In the current study, we showed that supplementation with germanium dioxide (GeO2) in CBA/J mice resulted in SNHL due to the degeneration of the stria vascularis and spiral ganglion, which were associated with ...
SPINE - NEUROPATHIC PAIN

Hydrogen-Rich Saline Attenuates Chronic Allodynia after Bone Fractures via Reducing Spinal ...

Year Published: 2022

Purpose: Neuroinflammation often initiates iron overload in the pathogenesis of neurological disorders. Chemokine-driven neuroinflammation is required for central sensitization and chronic allodynia following fractures, but specific molecular modulations are elusive. This present study explored whether hydrogen-rich saline, as one potent anti-inflammatory pharmaceutical, could alleviate ...
KIDNEY - ACUTE KIDNEY INJURY

Effect of water diuresis with hydrogen saturation on the course of acute kidney damage during the ...

Year Published: 2022

Molecular hydrogen has the ability to penetrate cells, easily reach mitochondria, overcome body barriers, penetrate areas of ischemia, edema and inflammation, improve energy supply by supplying additional electrons and have antioxidant and anti-inflammatory effects by neutralizing highly reactive hydroxyl radical and peroxynitrite. In this experiment, we included 60 nonlinear male rats weighing ...
BRAIN - BRAIN INJURY

Pharmacokinetics of hydrogen administered intraperitoneally as hydrogen-rich saline and its effect ...

Year Published: 2022

Intraperitoneal administration of hydrogen (H2)-containing saline inhibited neuronal cell death in ischemic stroke in a number of animal models, but it is unknown whether H2 is absorbed from the abdominal cavity into the blood and reaches the brain. In this study, we investigated whether intraperitoneal administration of saline containing H2 inhibits neuronal cell death caused by cerebral ischemia ...
BONE - OSTEOARTHRITIS

Injectable spontaneous hydrogen-releasing hydrogel for long-lasting alleviation of osteoarthritis

Year Published: 2022

Excessive production of reactive oxygen species (ROS) amplifies pro-inflammatory pathways and exacerbates immune responses, and is a key factor in the progression of osteoarthritis (OA). Therapeutic hydrogen gas (H2) with antioxidative and anti-inflammatory effects, has a potential for OA alleviation, but the targeted delivery and sustained release of H2 are still challenging. Herein, we develop ...
INTESTINE - SURGERY/TRANSPLANTATION

Hydrogen gas and preservation of intestinal stem cells in mesenteric ischemia and reperfusion

Year Published: 2022

Background: Patients with mesenteric ischemia frequently suffer from bowel necrosis even after revascularization. Hydrogen gas has showed promising effects for ischemia-reperfusion injury by reducing reactive oxygen species in various animal and clinical studies. We examined intestinal tissue injury by ischemia and reperfusion under continuous initiation of 3% hydrogen gas. Aim: To clarify the ...
WHOLE BODY - CANCER

Enzyme-Triggered Size-Switchable Nanosystem for Deep Tumor Penetration and Hydrogen Therapy

Year Published: 2023

The poor penetration of nanocarriers within tumor dense extracellular matrices (ECM) greatly restricts the access of anticancer drugs to the deep tumor cells, resulting in low therapeutic efficacy. Moreover, the high toxicity of the traditional chemotherapeutics inevitably causes undesirable side effects. Herein, taking the advantages of biosafe H2 and small-sized nanoparticles in diffusion within ...
WHOLE BODY - DIABETES (TYPE II)

The Effects of Alkaline Ionized Water Administration to the Total Cholesterol Levels in Patients ...

Year Published: 2021

Background: Total cholesterol is a measure of the total amount of cholesterol components including LDL (low-density lipoprotein), HDL (high-density lipoprotein), and VLDL (very low-density lipoprotein). Alkaline ionized water (AIW) is an electrolyzed water with a hydrogen-rich molecule and an alkaline pH. It has a negative oxidation-reduction potential (ORP) and reactive oxygen species ...