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Studies Found: 55

WHOLE BODY - METABOLIC SYNDROME

Evaluation of the safety and potential lipid-lowering effects of oral hydrogen-rich coral calcium ...

Year Published: 2023

Background: Metabolic syndrome is characterized by a cluster-like occurrence of conditions such as hypertension, hyperglycaemia, elevated low-density lipoprotein (LDL) cholesterol or triglycerides (TG) and high visceral fat. Metabolic syndrome is linked to the build-up of plaque within the artery, which leads to disorders of the circulatory, nervous and immune systems. A variety of treatments ...
BRAIN - ALZHEIMER'S DISEASE

Therapeutic Inhalation of Hydrogen Gas for Alzheimer’s Disease Patients and Subsequent ...

Year Published: 2023

(1) Background: Alzheimer's disease (AD) is a progressive and fatal neurodegenerative disorder. Hydrogen gas (H2) is a therapeutic medical gas with multiple functions such as anti-oxidant, anti-inflammation, anti-cell death, and the stimulation of energy metabolism. To develop a disease-modifying treatment for AD through multifactorial mechanisms, an open label pilot study on H2 treatment was ...
BRAIN - CARDIAC ARREST

Efficacy of inhaled hydrogen on neurological outcome following brain ischaemia during post-cardiac ...

Year Published: 2023

Background: Inhaled molecular hydrogen gas (H2) has been shown to improve outcomes in animal models of cardiac arrest (CA). H2 inhalation is safe and feasible in patients after CA. We investigated whether inhaled H2 would improve outcomes after out-of-hospital CA (OHCA). Methods: HYBRID II is a prospective, multicentre, randomised, double-blind, placebo-controlled trial performed at 15 hospitals ...
WHOLE BODY - DIABETES (TYPE II)

Effectiveness and safety of hydrogen inhalation as an adjunct treatment in Chinese type 2 diabetes ...

Year Published: 2023

Aim: To analyze the effectiveness and safety of hydrogen inhalation (HI) therapy as an adjunct treatment in Chinese type 2 diabetes mellitus (T2DM) patients in a real-life clinical setting. Methods: This observational, non-interventional, retrospective, double-arm, 6-month clinical study included T2DM patients receiving conventional anti-diabetes medication with or without HI initiation from 2018 ...
BRAIN - NEUROPROTECTION

Hydrogen inhalation therapy regulates lactic acid metabolism following subarachnoid hemorrhage ...

Year Published: 2023

The neuroprotective effects of hydrogen have been demonstrated, but the mechanism is still poorly understood. In a clinical trial of inhaled hydrogen in patients with subarachnoid hemorrhage (SAH), we found that hydrogen reduced the accumulation of lactic acid in the nervous system. There are no studies demonstrating the regulatory effect of hydrogen on lactate and in this study we hope to further ...
BRAIN - ALZHEIMER'S DISEASE

Efficacy of donepezil plus hydrogen-oxygen mixture inhalation for treatment of patients with ...

Year Published: 2023

To investigate the clinical effect of donepezil combined with hydrogen-oxygen mixture inhalation in the treatment of patients with Alzheimer disease (AD), a total of 273 AD patients admitted to our hospital from March 2018 to March 2022 were retrospectively analyzed and assigned into an observation group (n = 138) and a control group (n = 135) according to the different treatment that they ...
WHOLE BODY - DIABETES (TYPE II)

Real-World Effectiveness and Safety of Hydrogen Inhalation in Chinese Patients with Type 2 Diabetes: ...

Year Published: 2023

Aim: To evaluate the real-life effectiveness and safety of Chinese patients with type 2 diabetes mellitus (T2DM) receiving hydrogen inhalation (HI) treatment as a supplementary treatment. Methods: This retrospective, multicenter, observational 6-months clinical study included T2DM patients maintaining HI, visited at 4 time points. The primary outcome is the mean change in glycated hemoglobin ...
BRAIN - ALZHEIMER'S DISEASE

Effects of Hydrogen Gas Inhalation on Community-Dwelling Adults of Various Ages: A Single-Arm, ...

Year Published: 2023

Molecular hydrogen (H2) is a versatile therapeutic agent. H2 gas inhalation is reportedly safe and has a positive impact on a range of illnesses, including Alzheimer's disease (AD). Herein, we investigated the effects of 4 weeks of H2 gas inhalation on community-dwelling adults of various ages. Fifty-four participants, including those who dropped out (5%), were screened and enrolled. The selected ...
WHOLE BODY - SARS/COVID

Effect of hydrogen/oxygen therapy for ordinary COVID-19 patients: a propensity-score matched ...

Year Published: 2023

Background: Hydrogen/oxygen therapy contribute to ameliorate dyspnea and disease progression in patients with respiratory diseases. Therefore, we hypothesized that hydrogen/oxygen therapy for ordinary coronavirus disease 2019 (COVID-19) patients might reduce the length of hospitalization and increase hospital discharge rates. Methods: This retrospective, propensity-score matched (PSM) case-control ...
BRAIN - OBESITY

Molecular hydrogen modulates brain glutamate/GABA-glutamine cycle in overweight humans

Year Published: 2023

Introduction: We evaluated whether 12-week intake of molecular hydrogen (H2) in 5 overweight adults (3 women; age: 50.2 ±11.9 years, body mass index: 29.4 ±2.1 kg/m2) affects brain levels of the glutamate-glutamine-GABA cycle, critical amino acid neurotransmitters in the mechanism of neuronal activation during appetite regulation. Methods: A 1.5-T single-voxel proton magnetic resonance ...
WHOLE BODY - SARS/COVID

Hydrogen-oxygen therapy alleviates clinical symptoms in twelve patients hospitalized with COVID-19: ...

Year Published: 2022

A global public health crisis caused by the 2019 novel coronavirus disease (COVID-19) leads to considerable morbidity and mortality, which bring great challenge to respiratory medicine. Hydrogen-oxygen therapy contributes to treat severe respiratory diseases and improve lung functions, yet there is no information to support the clinical use of this therapy in the COVID-19 pneumonia.A retrospective ...
WHOLE BODY - EXCERCISE

Molecular Hydrogen Mitigates Performance Decrement during Repeated Sprints in Professional Soccer ...

Year Published: 2022

Hydrogen-rich water (HRW) supplementation has been shown to have an antifatigue effect across different modes of exercise. However, its effect on repeated sprint performance is unknown. The aim of this study was to assess the effect of pre-exercise HRW consumption on repeated sprint performance, lactate, and perceptual responses using a repeated sprint protocol. This randomized, double blinded, ...
BRAIN - COMA

Hydrogen inhalation promotes recovery of a patient in persistent vegetative state from intracerebral ...

Year Published: 2022

Background: Persistent vegetative state (PVS) is a devastating and long-lasting clinical condition with high morbidity and mortality; currently, there are no available effective interventions. Case summary: We report the case of an 11-year-old boy with PVS caused by severe intracerebral bleeding in the left hemisphere following anticoagulation treatment. The patient's PVS severity showed no ...
WHOLE BODY - EXCERCISE

Short-Term Consumption of Hydrogen-Rich Water Enhances Power Performance and Heart Rate Recovery in ...

Year Published: 2022

(1) Background: Exercise that exceeds the body's accustomed load can lead to oxidative stress and increased fatigue during intense training or competition, resulting in decreased athletic performance and an increased risk of injury, and the new medicinal H2 may be beneficial as an antioxidant. Therefore, we explored the effect of short-term supplementation of hydrogen-rich water (HRW) on the work ...
BRAIN - ANXIETY

Effects of hydrogen water and psychological treatment in a sample of women with panic disorder: a ...

Year Published: 2022

Research suggests that inflammation is an important mediator in the pathophysiology of anxiety disorders. In addition, women are more likely to develop an anxiety and depression disorder, in comorbidity with a wide spectrum of diseases related to the immune system. In recent years, hydrogen-rich water has emerged as a promising therapeutic strategy to prevent and intervene in stress-related ...
WHOLE BODY - SARS/COVID

Hydrogen-rich water alleviates inflammation and fatigue in COVID-19: A pilot study

Year Published: 2022

No abstract available
WHOLE BODY - EXCERCISE

The Acute Effects of a Single Dose of Molecular Hydrogen Supplements on Responses to Ergogenic ...

Year Published: 2022

This research examined the effects of single-dose molecular hydrogen (H2) supplements on acid-base status and local muscle deoxygenation during rest, high-intensity intermittent training (HIIT) performance, and recovery. Ten healthy, trained subjects in a randomized, double-blind, crossover design received H2-rich calcium powder (HCP) (1500 mg, containing 2.544 μg of H2) or H2-depleted placebo ...
WHOLE BODY - HANGOVER

Hydrogen Intake Relieves Alcohol Consumption and Hangover Symptoms in Healthy Adults: a Randomized ...

Year Published: 2022

Background: Alcohol-induced hangover represents a significant, yet understudied, global hazard and a large socio-economic burden. Objectives: The aim of this study was to investigate the effects of hydrogen (H2) on relieving drinking and hangover symptoms in 20 healthy volunteers. Methods: In this pilot, randomized, double-blinded, placebo-controlled, matched, crossover interventional trial, ...
WHOLE BODY - SARS/COVID

Hydrogen effect on the mechanisms of mucosal immunity in patients with COVID-19

Year Published: 2022

Aim: To study the inhalation of an active form of hydrogen effect to mucosal and system immunity in a rehabilitation program for health workers. Materials and methods: The study involved patients that survived COVID-19 after therapy with inhaled hydrogen for 90 minutes (n=30), and a control group of patients treated according to standard protocol for managing patients that survived COVID-19 during ...
WHOLE BODY - HYDROGEN BIOLOGY

Antioxidant effects of continuous intake of electrolyzed hydrogen water in healthy adults

Year Published: 2022

Chronic oxidative stress induces deterioration of health and a risk for the onset of various diseases. Previous clinical studies revealed that electrolyzed hydrogen water (EHW) is effective to reduce oxidative stress during hemodialysis in patients with chronic dialysis. In the present observational study, we investigated the antioxidant effects of a daily continuous intake of EHW in healthy ...
WHOLE BODY - EXCERCISE

Effects of Alkaline-Reduced Water on Exercise-Induced Oxidative Stress and Fatigue in Young Male ...

Year Published: 2022

Regular physical activity confers health benefits and improves the general quality of life. Recently, alkaline-reduced water (ARW) consumption has garnered increasing attention in the field of sports. ARW effectively inhibits the oxidative stress generated in cells during high-intensity exercises; however, whether it exerts similar effects during exhaustive exercises remains unknown. This study ...
WHOLE BODY - EXCERCISE

Acute pre-exercise hydrogen rich water intake does not improve running performance at maximal ...

Year Published: 2022

Purpose: This study investigated the effects of acute, pre-exercise, hydrogen rich water (HRW) ingestion on running time to exhaustion at maximal aerobic speed in trained track and field runners. Methods: Twenty-four, male runners aged 17.5 ± 1.8 years, with body mass index = 21.0 ± 1.3 kg⋅m-2, and maximal oxygen uptake = 55.0 ± 4.6 ml⋅kg-1⋅min-1 (mean ± standard deviation) participated ...
BRAIN - SURGERY/TRANSPLANTATION

Hydrogen Gas Treatment Improves Postoperative Delirium and Cognitive Dysfunction in Elderly ...

Year Published: 2022

Purpose: Postoperative delirium is a state of acute brain dysfunction characterized by fluctuating mental status that affects millions of patients each year. We used prophylactic inhalation of hydrogen gas in elderly patients undergoing elective surgery to compare their occurrence of postoperative delirium with that of controls. Methods: A total of 184 patients aged ≥ 65 years were enrolled and ...
WHOLE BODY - DIABETES (TYPE II)

Electrolyzed hydrogen-rich water for oxidative stress suppression and improvement of insulin ...

Year Published: 2021

Introduction: Electrolyzed hydrogen-rich water (EHW) is known to have suppressive effects on oxidative stress (OS). However, its benefit in type 2 diabetes mellitus (T2DM) remains unclear. This study aimed to investigate the effect of EHW on T2DM. Methods: This was a multicenter, prospective, double-blind, randomized controlled trial of 50 patients with T2DM who were assigned to the EHW or ...
WHOLE BODY - EXCERCISE

Application of Molecular Hydrogen as an Antioxidant in Responses to Ventilatory and Ergogenic ...

Year Published: 2021

We investigated effects of molecular hydrogen (H2) supplementation on acid-base status, pulmonary gas exchange responses, and local muscle oxygenation during incremental exercise. Eighteen healthy, trained subjects in a randomized, double-blind, crossover design received H2-rich calcium powder (HCP) (1500 mg/day, containing 2.544 µg/day of H2) or H2-depleted placebo (1500 mg/day) for three ...