A novel bioactive haemodialysis system using dissolved dihydrogen (H2) produced by water electrolysis: a clinical trial
Hirofumi Nakano, Hiromi Hamada, Masaaki Nakayama, Noritomo Itami, Ryoichi Nakazawa, Sadayoshi Ito
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DOI:
10.1093/ndt/gfq196
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Abstract:
Background: Chronic inflammation in haemodialysis (HD) patients indicates a poor prognosis. However, therapeutic approaches are limited. Hydrogen gas (H(2)) ameliorates oxidative and inflammatory injuries to organs in animal models. We developed an HD system using a dialysis solution with high levels of dissolved H(2) and examined the clinical effects.
Methods: Dialysis solution with H(2) (average of 48 ppb) was produced by mixing dialysate concentrates and reverse osmosis water containing dissolved H(2) generated by a water electrolysis technique. Subjects comprised 21 stable patients on standard HD who were switched to the test HD for 6 months at three sessions a week.
Results: During the study period, no adverse clinical signs or symptoms were observed. A significant decrease in systolic blood pressure (SBP) before and after dialysis was observed during the study, and a significant number of patients achieved SBP <140 mmHg after HD (baseline, 21%; 6 months, 62%; P < 0.05). Changes in dialysis parameters were minimal, while significant decreases in levels of plasma monocyte chemoattractant protein 1 (P < 0.01) and myeloperoxidase (P < 0.05) were identified. Conclusions: Adding H(2) to haemodialysis solutions ameliorated inflammatory reactions and improved BP control. This system could offer a novel therapeutic option for control of uraemia.
| Publish Year |
2010 |
| Country |
Japan |
| Rank |
Positive |
| Journal |
Nephrology, Dialysis, and Transplantation |
| Primary Topic |
Kidney |
| Secondary Topic | Haemodialysis |
| Model |
Human |
| Tertiary Topic | Oxidative Stress |
| Vehicle |
Water (Electrolysis) |
| pH |
Alkaline |
| Application |
Injection |
| Comparison |
|
| Complement |
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