Hydrogen-rich water attenuates experimental periodontitis in a rat model
Daisuke Ekuni, Kenta Kasuyama, Koichiro Irie, Manabu Morita, Naofumi Tamaki, Takaaki Tomofuji, Tatsuji Azuma, Yasumasa Endo
Abstract:
Reactive oxygen species (ROS) contribute to the development of periodontitis. As molecular hydrogen can act as a scavenger of ROS, we examined the effects of treatment with hydrogen-rich water on a rat model of periodontitis. A ligature was placed around the maxillary molars for 4 weeks to induce periodontitis, and the animals were given drinking water with or without hydrogen-rich water. The rats with periodontitis which were treated with pure water showed a time-dependent increase in serum ROS level. Compared with the rats without periodontitis, the periodontitis-induced rats which were given pure water also showed polymorphonuclear leucocyte infiltration and alveolar bone loss at 4 weeks. Hydrogen-rich water intake inhibited an increase in serum ROS level and lowered expression of 8-hydroxydeoxyguanosine and nitrotyrosine in the periodontal tissue at 4 weeks. Such conditions prevented polymorphonuclear leucocyte infiltration and osteoclast differentiation following periodontitis progression. Furthermore, inflammatory signalling pathways, such as mitogen-activated protein kinases, were less activated in periodontal lesions from hydrogen-rich water-treated rats as compared with pure water-treated rats. Consuming hydrogen-rich water might be beneficial in suppressing periodontitis progression by decreasing gingival oxidative stress.
| Publish Year |
2011 |
| Country |
Japan |
| Rank |
Positive |
| Journal |
Journal of Clinical Periodontology |
| Primary Topic |
Mouth |
| Secondary Topic | Periodontitis |
| Model |
Rat |
| Tertiary Topic | Inflammation |
| Vehicle |
Water (Dissolved) |
| pH |
Neutral |
| Application |
Ingestion |
| Comparison |
|
| Complement |
|
Assessment of the effects of hydrogen water on human gingival fibroblast cell culture in patients ...
2023 - Mouth - Periodontitis
Background: Activated inflammatory cells produce reactive oxygen species (ROS) to eliminate pathogens. Under normal conditions, the pathogens are taken care of, and tissues are repaired. However, in periodontal disease, persistent inflammation causes ...
Molecular hydrogen suppresses Porphyromonas gingivalis lipopolysaccharide-induced increases in ...
2021 - Mouth - Periodontitis
Periodontitis is defined as a multifactorial polymicrobial infection accompanied by inflammatory reactions. Porphyromonas gingivalis (Pg) is known as a major pathogen in the initiation and progression of periodontitis, and a major virulence factor is ...
Assessment of antibacterial effect of hydrogen water on plaque from patients with chronic ...
2021 - Mouth - Periodontitis
Background: Periodontitis is an inflammatory disease causing destruction of tissues surrounding the teeth. The primary etiological factor for periodontitis is plaque. An inference could be drawn that an overall reduction in microorganisms halts ...
Assessment of the effects of hydrogen water on human gingival fibroblast cell culture in patients ...
2023 - Mouth - Periodontitis
Background: Activated inflammatory cells produce reactive oxygen species (ROS) to eliminate pathogens. Under normal conditions, the pathogens are taken care of, and tissues are repaired. However, in periodontal disease, persistent inflammation causes ...
Molecular hydrogen suppresses Porphyromonas gingivalis lipopolysaccharide-induced increases in ...
2021 - Mouth - Periodontitis
Periodontitis is defined as a multifactorial polymicrobial infection accompanied by inflammatory reactions. Porphyromonas gingivalis (Pg) is known as a major pathogen in the initiation and progression of periodontitis, and a major virulence factor is ...
Assessment of antibacterial effect of hydrogen water on plaque from patients with chronic ...
2021 - Mouth - Periodontitis
Background: Periodontitis is an inflammatory disease causing destruction of tissues surrounding the teeth. The primary etiological factor for periodontitis is plaque. An inference could be drawn that an overall reduction in microorganisms halts ...