Hydrogen-containing saline attenuates doxorubicin-induced heart failure in rats
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DOI:
10.1691/ph.2014.3859
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Abstract:
Interactions between doxorubicin (DOX) and iron generate reactive oxygen species and contribute to DOX-induced heart failure. Hydrogen, as a selective antioxidant, is a promising potential therapeutic option for the treatment of a variety of diseases. Therefore, we investigated the preventive effects of hydrogen treatment on DOX-induced heart failure in rats. We found that cardiac function was significantly improved and that the plasma levels of oxidative-stress markers and myocardial autophagic activity were decreased in animals treated with hydrogen-containing saline. Therefore, we conclude that hydrogen-containing saline may have beneficial effects for doxorubicin-induced heart failure.| Publish Year | 2014 |
|---|---|
| Country | China |
| Rank | Positive |
| Journal | Pharmazie |
| Primary Topic | Heart |
| Secondary Topic | Cancer |
| Model | Rat |
| Tertiary Topic | Chemotherapy Toxicity (Doxorubicin) |
| Vehicle | Saline (Dissolved) |
| pH | Neutral |
| Application | Injection |
| Comparison | |
| Complement |