Hepatic oxidoreduction-related genes are upregulated by administration of hydrogen-saturated drinking water
Bunpei Sato, Keiko Abe, Shinji Okada, Shota Ushiama, Soichi Arai, Yuji Nakai
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DOI:
10.1271/bbb.100819
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Abstract:
The effects of the administration of molecular hydrogen-saturated drinking water (hydrogen water) on hepatic gene expression were investigated in rats. Using DNA microarrays, 548 upregulated and 695 downregulated genes were detected in the liver after 4 weeks of administration of hydrogen water. Gene Ontology analysis revealed that genes for oxidoreduction-related proteins, including hydroxymethylglutaryl CoA reductase, were significantly enriched in the upregulated genes.
| Publish Year |
2014 |
| Country |
Japan |
| Rank |
Positive |
| Journal |
Bioscience, Biotechnology, and Biochemistry |
| Primary Topic |
Liver |
| Secondary Topic | ROS-Scavenging |
| Model |
Rat |
| Tertiary Topic | Oxidative Stress |
| Vehicle |
Water (Dissolved) |
| pH |
Neutral |
| Application |
Ingestion |
| Comparison |
|
| Complement |
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