A novel fluid resuscitation protocol: Provide more protection on acute kidney injury during septic shock in rats
Wei Liu, Xue-Song Dong, Yu-Qiang Sun, Zhi Liu
Abstract:
Objective: To investigate the therapeutic effects of a novel fluid resuscitation protocol (early fluid resuscitation plus 2% hydrogen inhalation) on acute kidney injury during septic shock induced by lipopolysaccharide in rats.
Methods: Sixty male Wistar rats were randomly divided into four groups (n = 15 per group): control group (C), septic shock group (S), septic shock with early fluid resuscitation group (R), and septic shock with early fluid resuscitation plus 2% hydrogen inhalation group (R+R+H2). The rats were ventilated, and a 2% hydrogen mixture was used in Group R+H2. Lipopolysaccharide (10 mg/kg) was administered to establish the septic shock model in rats and fluid resuscitation was performed in Groups R and R+R+H2.
Results: Fluid resuscitation with 2% hydrogen inhalation decreased serum creatinine, blood urea nitrogen, and neutrophil gelatinase-associated lipocalin. It also reduced oxidative stress injury and decreased renal tumor necrosis factor-α and interleukin-6 levels compared with fluid resuscitation alone.
Conclusion: Early fluid resuscitation plus 2% hydrogen inhalation provided more protection against AKI during septic shock.
| Publish Year |
2014 |
| Country |
China |
| Rank |
Positive |
| Journal |
International Journal of Clinical and Experimental Medicine |
| Primary Topic |
Kidney |
| Secondary Topic | Sepsis |
| Model |
Rat |
| Tertiary Topic | Inflammation |
| Vehicle |
Gas |
| pH |
N/A |
| Application |
Inhalation |
| Comparison |
|
| Complement |
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