Aerosol inhalation of a hydrogen-rich solution restored septic renal function
Anshun Guo, Chaojin Chen, Chenfang Luo, Haobo Li, Shan Wu, Shangrong Li, Weifeng Yao, Xue Han, Ziqing Hei
Read more:
DOI:
10.18632/aging.102542
DOI is the universal ID for this study.
This link will take you to the full study.
Abstract:
Sepsis-related acute kidney injury (AKI) is known to be caused by inflammation. We explored the renal protective effects of aerosol inhalation of a hydrogen-rich solution (HRS; hydrogen gas dissolved to saturation in saline) in a mouse model of septic AKI. Septic AKI was induced through 18 hours of cecal ligation and puncture. AKI occurred during the early stage of sepsis, as evidenced by increased blood urea nitrogen and serum creatinine levels, pathological changes, renal fibrosis and renal tubular epithelial cell apoptosis, accompanied by macrophage infiltration and M1 macrophage-associated pro-inflammatory cytokine (Il-6 and Tnf-α) generation in renal tissues. Aerosol inhalation of the HRS increased anti-inflammatory cytokine (Il-4 and Il-13) mRNA levels in renal tissues and promoted macrophage polarization to the M2 type, which generated additional anti-inflammatory cytokines (Il-10 and Tgf-β). Ultimately, aerosol inhalation of HRS protected the kidneys and increased survival among septic mice. HRS was confirmed to promote M2 macrophage polarization in lipopolysaccharide-stimulated RAW 264.7 cells. The TGF-β1 receptor inhibitor SB-431542 partly reversed the effects of HRS on renal function, fibrosis, tubular epithelial cell apoptosis and senescence in mice. Thus, HRS aerosol inhalation appears highly useful for renal protection and inflammation reduction in septic AKI.
| Publish Year |
2019 |
| Country |
China |
| Rank |
Positive |
| Journal |
Aging |
| Primary Topic |
Kidney |
| Secondary Topic | Sepsis |
| Model |
Mouse |
| Tertiary Topic | Inflammation |
| Vehicle |
Saline (Dissolved) |
| pH |
Neutral |
| Application |
Aerosol |
| Comparison |
|
| Complement |
|
Molecular hydrogen: prospective treatment strategy of kidney damage after cardiac surgery
2023 - Kidney - Surgery/Transplantation
Cardiac surgery-associated acute kidney injury (CS-AKI) is a common postoperative complication, mostly due increasing oxidative stress. Recently, molecular hydrogen (H2 gas), has also been applied to cardiac surgery due to its ability to reduce ...
Effect of water diuresis with hydrogen saturation on the course of acute kidney damage during the ...
2022 - Kidney - Acute Kidney Injury
Molecular hydrogen has the ability to penetrate cells, easily reach mitochondria, overcome body barriers, penetrate areas of ischemia, edema and inflammation, improve energy supply by supplying additional electrons and have antioxidant and ...
Inhalation of 4% and 67% hydrogen ameliorates oxidative stress, inflammation, apoptosis, and ...
2023 - Kidney - Acute Kidney Injury
Acute kidney injury (AKI) is the major complication of rhabdomyolysis (RM) clinically, which is usually mimicked by glycerol injection in basic research. Oxidative stress, inflammatory response and apoptosis are recognized to play important roles in ...
Hydrogen prevents lipopolysaccharide-induced pulmonary microvascular endothelial cell injury by ...
Background: Sepsis is a type of life-threatening organ dysfunction that is caused by a dysregulated host response to infection. The lung is the most vulnerable target organ under septic conditions. Pulmonary microvascular endothelial cells (PMVECs) ...
Micromotor-Enabled Active Hydrogen and Tobramycin Delivery for Synergistic Sepsis Therapy
2023 - Whole Body - Sepsis
Sepsis is a highly heterogeneous syndrome normally characterized by bacterial infection and dysregulated systemic inflammatory response that leads to multiple organ failure and death. Single anti-inflammation or anti-infection treatment exhibits ...
Hydrogen-rich saline regulates NLRP3 inflammasome activation in sepsis-associated encephalopathy rat ...
Sepsis-associated encephalopathy (SAE) is characterised by long-term cognitive impairment and psychiatric illness in sepsis survivors, associated with increased morbidity and mortality. There is a lack of effective therapeutics for SAE. Molecular ...