Molecular hydrogen downregulates acute exhaustive exercise-induced skeletal muscle damage
Adelino S.R. da Silva, Alisson L. da Rocha, Ana P. Pinto, Jonatas E. Nogueira, Luiz Guilherme S. Branco, Mateus R. Amorim
Read more:
DOI:
10.1139/cjpp-2020-0297
DOI is the universal ID for this study.
This link will take you to the full study.
Abstract:
Physical exercise-induced skeletal muscle damage may be characterized by increased oxidative stress, inflammation, and apoptosis which may be beneficial when exercise is regular, but it is rather harmful when exercise is exhaustive and performed acutely by unaccustomed individuals. Molecular hydrogen (H2) has emerged as a potent antioxidant, anti-inflammatory, and anti-apoptotic agent, but its action on the deleterious effects of acute exhaustive exercise in muscle damage remain unknown. Therefore, we tested the hypothesis that H2 decreases acute exhaustive exercise-induced skeletal muscle damage of sedentary rats. Rats ran to exhaustion on a sealed treadmill inhaling an H2-containing mixture or the control gas. We measured oxidative stress (SOD, GSH, and TBARS), inflammatory (TNF-α, IL-1β, IL-6, IL-10, and NF-kB phosphorylation) and apoptotic (expression of caspase-3, Bcl-2, and HSP70) markers. Exercise caused no changes in SOD activity but increased TBARS levels. H2 caused increases in exercise-induced SOD activity and blunted exercise-induced increased TBARS levels. We observed exercise-induced TNF-α and IL-6 surges as well as NF-kB phosphorylation, which were blunted by H2. Exercise increased cleaved caspase-3 expression, and H2 reduced this response. In conclusion, H2 effectively downregulates muscle damage, reducing oxidative stress, inflammation, and apoptosis after acute exhaustive exercise performed by an unaccustomed organism.
| Publish Year |
2020 |
| Country |
Brazil |
| Rank |
Positive |
| Journal |
Canadian Journal of Physiology and Pharmacology |
| Primary Topic |
Muscle |
| Secondary Topic | Excercise |
| Model |
Rat |
| Tertiary Topic | Fatigue |
| Vehicle |
Gas |
| pH |
N/A |
| Application |
Inhalation |
| Comparison |
|
| Complement |
|
Therapeutic Potential of Hydrogen-Rich Water on Muscle Atrophy Caused by Immobilization in a Mouse ...
2023 - Muscle - Disuse Atrophy
Skeletal muscle atrophy is associated with poor quality of life and disability. Thus, finding a new strategy for the prevention and treatment of skeletal muscle atrophy is very crucial. This study aimed to investigate the therapeutic potential of ...
A Comparison of the Antioxidant Effects Between Hydrogen Gas Inhalation and Vitamin C ...
2021 - Muscle - Excercise
The reactive oxygen species (ROS) produced during exercise act as a double-edged sword because they may cause oxidative damage but also play a role in the signaling pathways. A supplementation of exogenous antioxidants can reduce the total amount of ...
Open-label trial and randomized, double-blind, placebo-controlled, crossover trial of ...
2011 - Muscle - Muscular Dystrophy
Background: Molecular hydrogen has prominent effects on more than 30 animal models especially of oxidative stress-mediated diseases and inflammatory diseases. In addition, hydrogen effects on humans have been reported in diabetes mellitus type 2, ...
Acute pre-exercise hydrogen rich water intake does not improve running performance at maximal ...
2022 - Whole Body - Excercise
Purpose: This study investigated the effects of acute, pre-exercise, hydrogen rich water (HRW) ingestion on running time to exhaustion at maximal aerobic speed in trained track and field runners. Methods: Twenty-four, male runners aged 17.5 ± 1.8 ...
Effects of Alkaline-Reduced Water on Exercise-Induced Oxidative Stress and Fatigue in Young Male ...
2022 - Whole Body - Excercise
Regular physical activity confers health benefits and improves the general quality of life. Recently, alkaline-reduced water (ARW) consumption has garnered increasing attention in the field of sports. ARW effectively inhibits the oxidative stress ...
Effects of Intestinal Bacterial Hydrogen Gas Production on Muscle Recovery following Intense ...
2022 - Intestine - Excercise
This study aimed to examine the effects of hydrogen gas (H2) produced by intestinal microbiota on participant conditioning to prevent intense exercise-induced damage. In this double-blind, randomized, crossover study, participants ingested ...